SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
1Q96G36_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionAlpha tubulin-like.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005874 microtubule (IEA)
0005525 GTP binding (IEA)
0000166 nucleotide binding (IEA)
0005198 structural molecule activity (IEA)
0007018 microtubule-based movement (IEA)

Warning: fopen(/home/kongl/syndb/www/temp/824299059.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in all tubulin chains.swell as the bacterial FtsZ family of proteins. These proteinsare involved in polymer formation. Tubulin is the major componentof microtubules.hile FtsZ is the polymer-forming proteinof bacterial cell division.t is part of a ring in the middle of thedividing cell that is required for constriction of cell membrane andcell envelope to yield two daughter cells. FtsZ and tubulin are GTPases.his entry is the GTPase domain.FtsZ can polymerise into tubes.heets.nd rings in vitro and isubiquitous in bacteria and archaea.
  IPR003008:Tubulin/FtsZ, GTPase
Microtubules are polymers of tubulin. dimer of two 55-kDa subunits.esignated alpha and beta . Within the microtubule lattice.lpha-beta heterodimers associate in a head-to-tail fashion.iving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta-tubulin toward the plus end . For maximal rate and extent of polymerisation into microtubules.ubulin requires GTP. Two molecules of GTP are bound at different sites.ermed N and E. At the E (Exchangeable) site.TP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues.hich is found in both chains and is thought to controlaccess of the nucleotide to its binding site .Most species.xcepting simple eukaryotes.xpress a variety of closely-related alpha- and beta-isotypes. A third family member.amma tubulin.asalso been identified in a number of species. Gamma tubulin is found at microtubule-organising centres.uch as the spindle poles or the centrosome.uggesting that it is involved in minus-end nucleation of microtubule assembly .
  IPR000217:Tubulin
Microtubules are polymers of tubulin. dimer of two 55-kDa subunits.esignated alpha and beta . Within the microtubule lattice.lpha-beta heterodimers associate in a head-to-tail fashion.iving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta-tubulin toward the plus end . For maximal rate and extent of polymerisation into microtubules.ubulin requires GTP. Two molecules of GTP are bound at different sites.ermed N and E. At the E (Exchangeable) site.TP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues.hich is found in both chains and is thought to controlaccess of the nucleotide to its binding site .Most species.xcepting simple eukaryotes.xpress a variety of closely-related alpha- and beta-isotypes. A third family member.amma tubulin.asalso been identified in a number of species. Gamma tubulin is found at microtubule-organising centres.uch as the spindle poles or the centrosome.uggesting that it is involved in minus-end nucleation of microtubule assembly . More recently.psilon-tubulin has been identified in humans and Trypanosomes ; in humans.t has been localised to centrosomes .
  IPR004057:Epsilon tubulin
IPR003008:Tubulin 
Evalue:-24.9208183288574 
Location:27-118
SequencesProtein: Q96G36_HUMAN (154 aa)
mRNA: NM_145042
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 412 residues, 19692503-19693738Exon2: 71 residues, 19695672-19695879Exon3: 123 residues, 19698070-19698434Exon4: 2 residues, -Jump to Q96G36_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3299 19543291-19574108 ~-31K 24234(SNAP29)(+)Loci: 4560 19692503-19698434 ~-6K 24246(-)Loci: 3298 19191885-19271918 ~-80K 24223(PCQAP)(+)Link out to UCSC