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1Q96AG7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionCamp responsive element modulator, isoform b.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IEA)
0005515 protein binding (IEA)
0003700 transcription factor activity (IEA)
0006355 regulation of transcription, DNA-dependent (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner. CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB .
  IPR003102:Coactivator CBP, pKID
Transcription initiation is dictated by the presence and activity of specific nuclear factors that bind to DNA regulatory sequences and interact with the transcriptional machinery. The functions of some of these factors can be altered by phosphorylation.hich affects both DNA binding and transcriptional activation . Phosphorylation is effected by specific protein kinases that have been activated by the stimulus of signal transduction pathways.esulting in the regulation of gene transcription by modulating the phosphorylation sites of transcription factors.Cyclic AMP (cAMP) regulates the expression of many genes via a conserved gene promoter element CRE (cAMP response element) .hich has the sequence 5-TGACGTCA-3 . The cAMP response element binding protein (CREB) is a nuclear factor that is regulated by protein kinase A phosphorylation. Transcription is stimulated on binding to the CRE of a phosphorylated CREB dimer.hich is held together by leucine zippers. Dimerisation and transcriptional efficacy have been found to be stimulated by phosphorylation at several distinct sites.nd it has thus been suggested that CREB may be regulated by multiple kinases. Sequence analysis of the gene has revealed a cluster of protein kinase A.rotein kinase C.nd casein kinase II consensus recognition sites near the N-terminus of the protein sequence.nd the proximity of these sites to one another indicates the possibility of interaction in a positive or negative fashion to regulate CREB bioactivity.The leucine zipper (see ) is a structure that is believed to mediate the function of several eukaryotic gene regulatory proteins. The zipper consists of a periodic repetition of leucine residues at every seventh position.nd regions containing them appear to span 8 turns of alpha-helix. The leucine side chains that extend from one helix interact with those from a similar helix.ence facilitating dimerisation in the form of a coiled-coil. Leucine zippers are present in many gene regulatory proteins.ncluding the CREB proteins.un/AP1 transcription factors.os oncogene and fos-related proteins.-myc.-myc and N-myc oncogenes.nd so on.
  IPR001630:cAMP response element binding (CREB) protein
IPR003102:pKID 
Evalue:-17.5686359405518 
Location:50-91IPR001630:LEUZIPPRCREB 
Evalue:0 
Location:105-120
SequencesProtein: Q96AG7_HUMAN (137 aa)
mRNA: NM_001881
Local Annotation
Synapse Ontology
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 108 residues, 35455806-35456127Exon2: 43 residues, 35477301-35477425Exon3: 34 residues, 35507822-35507920Exon4: 239 residues, 35508067-35508780Exon5: 2 residues, -Jump to Q96AG7_HUMANExon1: 37 residues, 35456393-35456501Exon2: 34 residues, 35466715-35466813Exon3: 43 residues, 35477301-35477425Exon4: 34 residues, 35507822-35507920Exon5: 49 residues, 35508067-35508210Exon6: 65 residues, 35517133-35517322Exon7: 54 residues, 35535828-35535985Exon8: 436 residues, 35540589-35541891Exon9: 2 residues, -Jump to CREM_HUMAN  
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Loci Cluster (Details)Loci: 2612 35934343-35937869 ~-4K 4733(+)Loci: 3887 35967182-35970368 ~-3K 4734(FZD8)(-)Loci: 2611 35455806-35541891 ~-86K 4712(+)Link out to UCSC