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1Q8WYY7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein prenyltransferases catalyze the transfer of the carbon moiety of C15 farnesyl pyrophosphate or geranylgeranyl pyrophosphate synthase to a conserved cysteine residue in a CaaX motif of protein and peptide substrates. The addition of a farnesyl group is required to anchor proteins to the cell membrane. In the 3D structure of a mammalian Ras farnesyltransferases (Ftase).oth subunits are largely composed of alpha-helices. The alpha-2 to alpha-15 helices in the alpha subunit fold into a novel helical hairpin structure.esulting in a crescent-shape domain that envelopes part of the subunit. The 12 helices of the beta-subunit form an alpha-alpha barrel. Six additional helices connect the inner core of helices and form the outside of the helical barrel. A deep cleft surrounded by hydrophobic amino acids in the centre of the barrel is proposed as the FPP-binding pocket. A single Zn2+ ion is located at the junction between the hydrophilic surface groove near the subunit interface. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008940:Protein prenyltransferase
SequencesProtein: Q8WYY7_HUMAN (215 aa)
mRNA: AF289605
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 209 residues, 62252159-62252784Exon2: 90 residues, 62252870-62253134Exon3: 29 residues, 62257165-62257247Exon4: 281 residues, 62259429-62260267Exon5: 2 residues, -Jump to Q8WYY7_HUMANExon1: 203 residues, 62252527-62253134Exon2: 63 residues, 62259429-62259612Exon3: 117 residues, 62262335-62262681Exon4: 2 residues, -Jump to Q8N5M4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC