SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
1Q8WXA8_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
Description5-hydroxytryptamine receptor 3 subunit c.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0045211 postsynaptic membrane (IEA)
0005230 extracellular ligand-gated ion channel acti... (IEA)
0005216 ion channel activity (IEA)
0030594 neurotransmitter receptor activity (IEA)
0006811 ion transport (IEA)

Warning: fopen(/home/kongl/syndb/www/temp/1957399342.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006202:Neur_chan_LBD 
Evalue:-29.7447280883789 
Location:52-247IPR006029:Neur_chan_memb 
Evalue:-6.92081880569458 
Location:254-445
SequencesProtein: Q8WXA8_HUMAN (447 aa)
mRNA: NM_130770
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04821
  Level 3 annotation:
    5-hydroxytryptamine (serotonin) receptor 3C
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 185253528-185253629Exon2: 57 residues, 185255202-185255369Exon3: 17 residues, 185255793-185255838Exon4: 38 residues, 185256658-185256768Exon5: 58 residues, 185257356-185257526Exon6: 55 residues, 185258908-185259069Exon7: 70 residues, 185259917-185260122Exon8: 74 residues, 185260309-185260525Exon9: 176 residues, 185260631-185261153Exon10: 2 residues, -Jump to Q8WXA8_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4650 185120419-185218421 ~-98K 26910(ABCC5)(-)Loci: 3389 185233312-185239766 ~-6K 26914(+)Loci: 3390 185253528-185261153 ~-8K 26916(+)Loci: 3391 185375327-185384572 ~-9K 26927(AP2M1)(+)Loci: 4649 185029867-185085387 ~-56K 26908(PSARL)(-)Link out to UCSC