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1Q8WWG8_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionKainate receptor subunit ka2a.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016020 membrane (IEA)
0005234 glutamate-gated ion channel activity (IEA)
0005216 ion channel activity (IEA)
0004970 ionotropic glutamate receptor activity (IEA)
0005267 potassium channel activity (IEA)
0004872 receptor activity (IEA)
0005215 transporter activity (IEA)
0006811 ion transport (IEA)
0006813 potassium ion transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor.amely NMDA (N-methyl-D-aspartate).MPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionicacid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain.ransient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission .
  IPR001320:Ionotropic glutamate receptor
InterPro domains unassigned to SynO:
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
N-Methyl-D-aspartate (NMDA) receptors are members of the glutamate receptorchannel superfamily.hich mediate most of the fast excitory synaptictransmissions in the central nervous system. The superfamily consists of 3subtypes: kainate receptors.lpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl-D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses.hich is believed to underlie memory and learning.s well as the development of the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia.troke.lzheimers disease.ndHuntingdons disease .NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation.esulting in influx of calcium ions into the cell . Thereceptors can also be activated by polyamine.hey can be blocked bymagnesium ions.nhibited by zinc ions.nd modulated by arachidonic acid.Other non-NMDA glutamate receptors (e.g..ainate) are structurally similarto NMDA receptors.ut are functionally distinct.ossibly as a result ofamino acid substitutions at important positions in the sequence.
  IPR001508:NMDA receptor
IPR001320:Lig_chan 
Evalue:-152.552841186523 
Location:543-825IPR001828:ANF_receptor 
Evalue:-60.0087738037109 
Location:39-382IPR001508:NMDARECEPTOR 
Evalue:0 
Location:460-488
SequencesProtein: Q8WWG8_HUMAN (981 aa)
mRNA: AJ249209
Local Annotation
Synapse Ontology
Either stimulating afferents at high frequency or by directly depolarizing the postsynaptic cell with current injection leads to the Magnalium leaving the AMDAR, then calium and sodium enter the postsynaptic cell and trigger for LTP
sdb:0248 NMDA receptor-dependent LTP  (Evidence:domains)
?
sdb:0263 presynaptic LTP  (Evidence:domains)
KO assignmentK05205
  Level 3 annotation:
    glutamate receptor, ionotropic, kainate 5
  Level 2 annotation:
    Neuroactive ligand-receptor interaction
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 327 residues, 47194312-47195291Exon2: 42 residues, 47199323-47199445Exon3: 45 residues, 47199546-47199675Exon4: 77 residues, 47201714-47201940Exon5: 57 residues, 47202636-47202802Exon6: 60 residues, 47217292-47217466Exon7: 38 residues, 47217938-47218048Exon8: 40 residues, 47218232-47218346Exon9: 70 residues, 47238543-47238747Exon10: 38 residues, 47249593-47249701Exon11: 37 residues, 47249816-47249921Exon12: 53 residues, 47250311-47250464Exon13: 56 residues, 47252653-47252815Exon14: 20 residues, 47252916-47252970Exon15: 61 residues, 47255340-47255519Exon16: 57 residues, 47258479-47258645Exon17: 34 residues, 47258749-47258847Exon18: 57 residues, 47261214-47261379Exon19: 40 residues, 47261683-47261797Exon20: 2 residues, -Jump to GRIK5_HUMANExon1: 253 residues, 47197782-47198538Exon2: 42 residues, 47199323-47199445Exon3: 45 residues, 47199546-47199675Exon4: 77 residues, 47201714-47201940Exon5: 57 residues, 47202636-47202802Exon6: 60 residues, 47217292-47217466Exon7: 38 residues, 47217938-47218048Exon8: 40 residues, 47218232-47218346Exon9: 70 residues, 47238543-47238747Exon10: 38 residues, 47249593-47249701Exon11: 37 residues, 47249816-47249921Exon12: 53 residues, 47250311-47250464Exon13: 56 residues, 47252653-47252815Exon14: 20 residues, 47252916-47252970Exon15: 61 residues, 47255340-47255519Exon16: 57 residues, 47258479-47258645Exon17: 34 residues, 47258749-47258847Exon18: 57 residues, 47261214-47261379Exon19: 40 residues, 47261683-47261797Exon20: 2 residues, -Jump to Q8WWG8_HUMAN  
Loci Cluster (Details)Loci: 4393 47162575-47190222 ~-28K 18940(ATP1A3)(-)Loci: 4394 47194312-47261797 ~-67K 18941(GRIK5)(-)Loci: 4395 47286962-47340851 ~-54K 18946(POU2F2)(-)Loci: 4396 47394591-47413653 ~-19K 18951(DEDD2)(-)Loci: 4392 47152677-47155311 ~-3K 18939(RABAC1)(-)Link out to UCSC