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1Q8NDQ1_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical protein dkfzp547i1415.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (IEA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
SequencesProtein: Q8NDQ1_HUMAN (139 aa)
mRNA: AL832321
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 719 residues, 89331265-89333421Exon2: 32 residues, 89467637-89467728Exon3: 36 residues, 89468622-89468724Exon4: 17 residues, 89486193-89486239Exon5: 34 residues, 89490002-89490098Exon6: 41 residues, 89490451-89490568Exon7: 2 residues, -Jump to Q8NDQ1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2856 89491998-89580859 ~-89K 11593(TDP1)(+)Loci: 2857 89933128-89941704 ~-9K 11603(CALM1)(+)Loci: 4144 89331265-89490568 ~-159K 11590(-)Link out to UCSC