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1Q8NCN5_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionKiaa1990 protein (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IEA)
0004047 aminomethyltransferase activity (IEA)
0016491 oxidoreductase activity (IEA)
0006118 electron transport (IEA)
0006546 glycine catabolism (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of glycine cleavage T-proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondriaof eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes.The T-protein is an aminomethyl transferase that catalyses the following reaction:(6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5.0-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein
  IPR006222:Glycine cleavage T protein (aminomethyl transferase)
This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase ().arcosine oxidase beta subunit ().-alanine oxidase ().-aspartate oxidase (). D-amino acid oxidase () (DAMOX or DAO) is an FAD flavoenzyme that catalyzes the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterized and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes. D-aspartate oxidase () (DASOX) is an enzyme.tructurally related to DAO.hich catalyzes the same reaction but is active only toward dicarboxylic D-amino acids. In DAO. conserved histidine has been shown to be important for the enzymes catalytic activity.
  IPR006076:FAD dependent oxidoreductase
This entry shows glycine cleavage T-proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
  IPR013977:Glycine cleavage T-protein, C-terminal barrel
IPR006222:GCV_T 
Evalue:-95.0043640136719 
Location:527-744IPR006076:DAO 
Evalue:-91.0457611083984 
Location:48-406IPR013977:GCV_T_C 
Evalue:-36.9208183288574 
Location:751-860
SequencesProtein: Q8NCN5_HUMAN (883 aa)
mRNA: NM_017990
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 272 residues, 68705029-68705844Exon2: 38 residues, 68706224-68706334Exon3: 88 residues, 68711864-68712123Exon4: 46 residues, 68718663-68718797Exon5: 29 residues, 68720187-68720269Exon6: 56 residues, 68720362-68720526Exon7: 42 residues, 68721826-68721948Exon8: 41 residues, 68722705-68722823Exon9: 52 residues, 68723554-68723704Exon10: 66 residues, 68727597-68727790Exon11: 43 residues, 68730302-68730427Exon12: 54 residues, 68733637-68733793Exon13: 46 residues, 68733956-68734090Exon14: 51 residues, 68734913-68735062Exon15: 39 residues, 68735824-68735937Exon16: 33 residues, 68737537-68737632Exon17: 32 residues, 68739867-68739957Exon18: 63 residues, 68744794-68744977Exon19: 1604 residues, 68747878-68752685Exon20: 2 residues, -Jump to Q8NCN5_HUMAN  
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