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1Q8N9F0_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein flj37478.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008080 N-acetyltransferase activity (IEA)
0016740 transferase activity (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Histone acetylation is carried out by a class of enzymes known as histone acetyltransferases (HATs).hich catalyze the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. Early indication that HATs were involved in transcription came from the observation that in actively transcribed regions of chromatin.istones tend to be hyperacetylated.hereas in transcriptionally silent regions histones are hypoacetylated. The histone acetyltransferases are divided into five families. These include the Gcn5-related acetyltransferases (GNATs); the MYST (for MOZ.bf2/Sas3.as2 and Tip60)-related HATs; p300/CBP HATs; the general transcription factor HATs.hich include the TFIID subunit TAF250; and the nuclear hormone-related HATs SRC1 and ACTR (SRC3).The GCN5-related N-acetyltransferase superfamily includes such enzymes as the histone acetyltransferases GCN5 and Hat1.he elongator complex subunit Elp3.he mediator-complex subunit Nut1.nd Hpa2 . Many GNATs share several functional domains.ncluding an N-terminal region of variable length.n acetyltransferase domain that encompasses the conserved sequence motifs described above. region that interacts with the coactivator Ada2.nd a C-terminal bromodomain that is believed to interact with acetyl-lysine residues. Members of the GNAT family are important for the regulation of cell growth and development. In mice.nockouts of Gcn5L are embryonic lethal. Yeast Gcn5 is needed for normal progression through the G2M boundary and mitotic gene expression. The importance of GNATs is probably related to their role in transcription and DNA repair.The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. The crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) shows that Hat1 has an elongated.urved structure.nd the AcCoA molecule is bound in a cleft on the concave surface of the protein.arking the active site of the enzyme. A channel of variable width and depth that runs across the protein is probably the binding site for the histone substrate . The central protein core associated with AcCoA binding that appears to be structurally conserved among a superfamily of N-acetyltransferases.ncluding yeast histone acetyltransferase 1 and Serratia marcescens aminoglycoside 3-N-acetyltransferase .
  IPR000182:GCN5-related N-acetyltransferase
IPR000182:Acetyltransf_1 
Evalue:-17.7212467193604 
Location:17-97
SequencesProtein: Q8N9F0_HUMAN (134 aa)
mRNA: NM_178557
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 10 residues, 2031384-2031412Exon2: 57 residues, 2032522-2032687Exon3: 718 residues, 2035284-2037433Exon4: 2 residues, -Jump to Q8N9F0_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4661 1784557-1827772 ~-43K 27218(LETM1)(-)Loci: 3399 2031384-2037433 ~-6K 27229(+)Loci: 3400 2440604-2487379 ~-47K 27243(RNF4)(+)Loci: 3398 1765420-1780396 ~-15K 27216(FGFR3)(+)Link out to UCSC