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1Q8N4B8_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionGolgi snap receptor complex member 2, isoform c.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0004872 receptor activity (IEA)
0006886 intracellular protein transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
A crucial step in membrane fusion is the formation of the SNARE complex in which conserved regions.alled SNARE motifs.rom individual SNAREs associate and twist to form the core complex.hich is an all-parallel coiled coil. The neuronal SNARE complex is a heterotrimer of vesicular (v-) SNARE VAMP-2 and the two target plasma membrane (t-) SNAREssyntaxin 1A and SNAP-25. It has been proposed that SNARE core complex formation proceeds like a zipper.eginning at themembrane-distal region and propagating toward themembrane-proximal end. SNARE complex formation is an energy-releasing process that may supply the required freeenergy for membrane fusion .This family includes the Golgi SNAP receptor (SNARE) complex protein.hich is involved in transport from the endoplasmic reticulum to the golgi apparatus and intra-golgi transport.nd the vesicle transport v-SNARE protein.hat mediates vesicle transport pathways through interaction with T-SNAREs on the target membrane.
  IPR007705:Vesicle transport v-SNARE
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
  IPR010989:t-snare
IPR007705:V-SNARE 
Evalue:-11.7212467193604 
Location:37-159
SequencesProtein: Q8N4B8_HUMAN (195 aa)
mRNA: NM_001012511
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 42355484-42355586Exon2: 23 residues, 42361884-42361949Exon3: 38 residues, 42363463-42363572Exon4: 46 residues, 42364431-42364564Exon5: 49 residues, 42367393-42367534Exon6: 924 residues, 42370963-42373731Exon7: 2 residues, -Jump to GOSR2_HUMANExon1: 35 residues, 42355484-42355586Exon2: 23 residues, 42361884-42361949Exon3: 38 residues, 42363463-42363572Exon4: 46 residues, 42364431-42364564Exon5: 605 residues, 42367393-42369202Exon6: 2 residues, -Jump to Q8N4B8_HUMAN  
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