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1Q8IZD0_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms . SAM domains have been shown to homo- and hetero-oligomerise.orming multiple self-association architectures and also binding to various non-SAM domain-containing proteins .evertheless with a low affinity constant . SAM domains also appear to possess the ability to bind RNA . Smaug a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA binds to the 3 untranslated region (UTR) of nos mRNA via two similar hairpin structures. The 3D crystal structure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain.hich could be the RNA-binding surface. This electropositive potential is unique among all previously determined SAM-domain structures and is conserved among Smaug-SAM homologs. These results suggest that the SAM domain might have a primary role in RNA binding. Structural analyses show that the SAM domain is arranged in a small five-helix bundle with two large interfaces . In the case of the SAM domain of EphB2.ach of these interfaces is able to form dimers. The presence of these two distinct intermonomers binding surface suggest that SAM could form extended polymeric structures .
  IPR001660:Sterile alpha motif SAM
Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions.ssociating with both SAM-containing and non-SAM-containing proteins pathway . SAM domains exhibit a conserved structure.onsisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function.eing involved in interactions with proteins.NA and RNA . The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names.ncluding SPM.TN (pointed).EP (yeast sterility.ts-related.cG proteins).CR (N-terminal conserved region) and HLH (helix-loop-helix) domain.ll of which are related and can be classified as SAM domains. SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains.ncluding Ets-1 transcription factor.hich plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases ; Etv6 transcription factor.ene rearrangements of which have been demonstrated in several malignancies ; EphA4 receptor tyrosine kinase.hich is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord ; EphB2 receptor.hich is involved in spine morphogenesis via intersectin.dc42 and N-Wasp ; p73. p53 homologue involved in neuronal development ; and polyhomeotic.hich is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes .
  IPR013761:Sterile alpha motif-type
SequencesProtein: Q8IZD0_HUMAN (445 aa)
mRNA: NM_174920
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
a kind of potentiation that decays over a course of more than 20 min. long-lasting forms of LTP and LTD have been identified that require new gene expression and protein synthesis.
sdb:0192 long-term plasticity  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 126 residues, 45545034-45545411Exon2: 54 residues, 45546286-45546442Exon3: 42 residues, 45546549-45546669Exon4: 30 residues, 45546719-45546803Exon5: 55 residues, 45547926-45548086Exon6: 27 residues, 45548192-45548267Exon7: 31 residues, 45548365-45548453Exon8: 98 residues, 45549769-45550058Exon9: 57 residues, 45550523-45550690Exon10: 20 residues, 45557279-45557334Exon11: 97 residues, 45561879-45562166Exon12: 2 residues, -Jump to Q8IZD0_HUMAN  
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Loci Cluster (Details)Loci: 4299 45545034-45562166 ~-17K 16176(-)Loci: 3018 45598389-45608288 ~-10K 16177(SGCA)(+)Loci: 4300 45800227-45805561 ~-5K 16185(MRPL27)(-)Loci: 3019 45965097-45975160 ~-10K 16195(EPN3)(+)Loci: 3020 45993447-46059430 ~-66K 16202(CACNA1G)(+)Loci: 3021 46067226-46124061 ~-57K 16218(ABCC3)(+)Loci: 3017 45527694-45543421 ~-16K 16175(PDK2)(+)Link out to UCSC