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1Q8IWA7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionRab37, member ras oncogene family, isoform 3.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005525 GTP binding (IEA)
0000166 nucleotide binding (IEA)
0015031 protein transport (IEA)
0007264 small GTPase mediated signal transduction (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-89.0177287669604 
Location:23-187
SequencesProtein: Q8IWA7_HUMAN (216 aa)
mRNA: NM_175738
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 177 residues, 70178864-70179392Exon2: 39 residues, 70236989-70237100Exon3: 16 residues, 70249987-70250029Exon4: 24 residues, 70250862-70250929Exon5: 19 residues, 70251021-70251074Exon6: 24 residues, 70252041-70252107Exon7: 21 residues, 70252606-70252663Exon8: 27 residues, 70252741-70252818Exon9: 55 residues, 70253039-70253198Exon10: 191 residues, 70254499-70255068Exon11: 2 residues, -Jump to Q8IWA7_HUMANExon1: 49 residues, 70244955-70245099Exon2: 39 residues, 70248501-70248612Exon3: 16 residues, 70249987-70250029Exon4: 24 residues, 70250862-70250929Exon5: 19 residues, 70251021-70251074Exon6: 24 residues, 70252041-70252107Exon7: 21 residues, 70252606-70252663Exon8: 27 residues, 70252741-70252818Exon9: 453 residues, 70253039-70254394Exon10: 2 residues, -Jump to RAB37_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3038 70178864-70255068 ~-76K 16552(+)Loci: 3039 70256378-70277089 ~-21K 16559(SLC9A3R1)(+)Loci: 4310 70349762-70367602 ~-18K 16565(GRIN2C)(-)Loci: 4311 70370220-70380710 ~-10K 16567(FDXR)(-)Loci: 4312 70546549-70554669 ~-8K 16577(ATP5H)(-)Loci: 4313 70637918-70639472 ~-2K 16582(NT5C)(-)Loci: 4314 70744289-70769272 ~-25K 16589(GGA3)(-)Loci: 4315 70780668-70797109 ~-16K 16594(SLC25A19)(-)Loci: 4316 71265612-71272875 ~-7K 16620(GALK1)(-)Loci: 4317 71514521-71534972 ~-20K 16639(EVPL)(-)Loci: 4318 71546785-71580202 ~-33K 16642(SRP68)(-)Loci: 3040 71582486-71585168 ~-3K 16644(GALR2)(+)Loci: 3041 71586857-71590480 ~-4K 16645(+)Loci: 4319 71588681-71611451 ~-23K 16647(EXOC7)(-)Loci: 3037 69833964-69859062 ~-25K 16537(+)Link out to UCSC