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1Q8IVX7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionEya3 protein (eyes absent homolog 3) (drosophila).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003824 catalytic activity (IEA)
0007275 development (IEA)
0008152 metabolism (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye.uscle.idney and ear. Eyes absent is a nuclear transcription factor.cting through interaction withhomeodomain-containing Sine oculis (also known as Six) proteins. Eyes absent is also a protein tyrosine phosphatase It does not resemble theclassical tyrosine phosphatases that use cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. Rather.yes absent is the prototype fora class of protein tyrosine phosphatases that use a nucleophilic aspartic acid in a metal-dependent reaction. Furthermore.he phosphatase activity of Eyes absentcontributes to its ability to induce eye formation in drosophila. Thus.yes absent belongs to thephosphatase subgroup of the haloacid dehalogenase (HAD) superfamily and appears to act as a nuclear transcriptional coactivator with intrinsic phosphatase activity.The Eyes absent proteins contain a divergent 200300-residue.mino-terminal region and a conserved carboxy-terminal domain of 271274 residues (EYA domain).hich iscritical for activity and believed to participate in proteinprotein interactions
  IPR006545:EYA
IPR005834:Hydrolase 
Evalue:-9.27572441101074 
Location:257-501
SequencesProtein: Q8IVX7_HUMAN (536 aa)
mRNA: BC041667
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01104
  Level 3 annotation:
    protein-tyrosine phosphatase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 80 residues, 28173405-28173644Exon2: 35 residues, 28177471-28177572Exon3: 42 residues, 28187632-28187754Exon4: 40 residues, 28188794-28188909Exon5: 55 residues, 28192497-28192658Exon6: 21 residues, 28196417-28196476Exon7: 32 residues, 28199057-28199147Exon8: 30 residues, 28203433-28203517Exon9: 48 residues, 28210044-28210184Exon10: 63 residues, 28212208-28212392Exon11: 30 residues, 28216251-28216337Exon12: 48 residues, 28226886-28227024Exon13: 47 residues, 28234641-28234778Exon14: 24 residues, 28237936-28238003Exon15: 28 residues, 28241668-28241748Exon16: 16 residues, 28247480-28247524Exon17: 35 residues, 28257091-28257192Exon18: 34 residues, 28287621-28287718Exon19: 2 residues, -Jump to EYA3_HUMANExon1: 39 residues, 28176372-28176487Exon2: 35 residues, 28177471-28177572Exon3: 42 residues, 28187632-28187754Exon4: 40 residues, 28188794-28188909Exon5: 55 residues, 28192497-28192658Exon6: 21 residues, 28196417-28196476Exon7: 32 residues, 28199057-28199147Exon8: 30 residues, 28203433-28203517Exon9: 48 residues, 28210044-28210184Exon10: 63 residues, 28212208-28212392Exon11: 30 residues, 28216251-28216337Exon12: 47 residues, 28234641-28234778Exon13: 24 residues, 28237936-28238003Exon14: 28 residues, 28241668-28241748Exon15: 16 residues, 28247480-28247524Exon16: 35 residues, 28257091-28257192Exon17: 15 residues, 28287621-28287662Exon18: 2 residues, -Jump to Q8IVX7_HUMAN  
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Loci Cluster (Details)Loci: 2494 27120810-27145474 ~-25K 818(NUDC)(+)Loci: 2495 27192784-27199731 ~-7K 822(+)Loci: 2496 27541099-27553008 ~-12K 833(SYTL1)(+)Loci: 3786 27604712-27689256 ~-85K 852(WASF2)(-)Loci: 2497 27972369-28023401 ~-51K 864(STX12)(+)Loci: 3787 28173405-28287718 ~-114K 879(EYA3)(-)Loci: 2493 27062219-27063534 ~-1K 814(SFN)(+)Link out to UCSC