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1Q86SI1_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionSarcosynapsin.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IEA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
This domain is found associated with and .
  IPR011705:BTB/Kelch-associated
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
Kelch is a 50-residue motif.amed after the Drosophila mutant in which it was first identified . The motif appears 6 times in Drosophila egg-chamber regulatory protein.nd is also found in mouse protein MIPP and in a number of poxviruses. In addition.elch repeats have been recognised in alpha- and beta-scruin and in galactose oxidase from the fungus Dactylium dendroides . The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold .The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function.s it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila . Nevertheless.ased on the location of the kelch pattern in the catalytic unit in galactose oxidase.unctionally important residues have been predicted in glyoxal oxidase .
  IPR006652:Kelch repeat
Galactose oxidase () is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde . The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation . Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich.he central domain forms a seven 4-bladed beta-propeller.nd the C-terminal domain has an immunoglobulin-like fold.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011043:Galactose oxidase, central
IPR013069:BTB 
Evalue:-36.0809211730957 
Location:23-128IPR011705:BACK 
Evalue:-33.4948501586914 
Location:133-239IPR006652:Kelch 
Evalue:-8.88605664769316 
Location:463-510IPR006652:Kelch_1 
Evalue:-5.92081880569458 
Location:401-449IPR006652:Kelch_1 
Evalue:-4.92081880569458 
Location:546-594IPR006652:Kelch_1 
Evalue:-1.09151494503021 
Location:348-399
SequencesProtein: Q86SI1_HUMAN (621 aa)
mRNA: NM_152393
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 418 residues, 42702014-42703266Exon2: 55 residues, 42704637-42704798Exon3: 38 residues, 42705105-42705213Exon4: 64 residues, 42705364-42705550Exon5: 51 residues, 42707354-42707501Exon6: 190 residues, 42708377-42708942Exon7: 2 residues, -Jump to Q86SI1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3351 42702014-42708942 ~-7K 25499(+)Loci: 4596 42564476-42598432 ~-34K 25489(-)Link out to UCSC