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1Q6ZT11_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein flj45056.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0045211 postsynaptic membrane (IEA)
0005230 extracellular ligand-gated ion channel acti... (IEA)
0030594 neurotransmitter receptor activity (IEA)
0006811 ion transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
IPR006029:Neur_chan_memb 
Evalue:-16.3979396820068 
Location:20-128
SequencesProtein: Q6ZT11_HUMAN (133 aa)
mRNA: AK127001
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 57 residues, 46728335-46728505Exon2: 32 residues, 46728687-46728779Exon3: 24 residues, 46729190-46729258Exon4: 75 residues, 46858022-46858243Exon5: 29 residues, 47016900-47016983Exon6: 48 residues, 47100091-47100229Exon7: 53 residues, 47100332-47100485Exon8: 83 residues, 47103455-47103700Exon9: 253 residues, 47122447-47123202Exon10: 2 residues, -Jump to GBRB1_HUMANExon1: 1149 residues, 47119517-47122963Exon2: 2 residues, -Jump to Q6ZT11_HUMAN  
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