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1Q6ZT07_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein flj45076.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (IEA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST.hich areGTPase activator proteins of yeast Ypt6 and Ypt7.mply that these domainsare GTPase activator proteins of Rab-like small GTPases .
  IPR000195:RabGAP/TBC
The GRAM domain is found in in glucosyltransferases.yotubularins and other putative membrane-associated proteins.
  IPR004182:GRAM
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR000195:TBC 
Evalue:-67.3010330200195 
Location:359-571IPR004182:GRAM 
Evalue:-24.5850257873535 
Location:140-208IPR004182:GRAM 
Evalue:-18.1938209533691 
Location:1-60IPR002048:efhand 
Evalue:-2.35654735565186 
Location:737-765
SequencesProtein: Q6ZT07_HUMAN (1015 aa)
mRNA: AB020689 AK127020 NM_015130
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 563 residues, 141761386-141763074Exon2: 53 residues, 141763368-141763521Exon3: 36 residues, 141764719-141764823Exon4: 27 residues, 141764917-141764992Exon5: 31 residues, 141768044-141768131Exon6: 24 residues, 141768903-141768969Exon7: 82 residues, 141774551-141774792Exon8: 25 residues, 141779689-141779758Exon9: 35 residues, 141779933-141780032Exon10: 45 residues, 141797700-141797830Exon11: 97 residues, 141798130-141798416Exon12: 41 residues, 141800191-141800309Exon13: 73 residues, 141802496-141802711Exon14: 52 residues, 141809520-141809671Exon15: 59 residues, 141810237-141810408Exon16: 71 residues, 141811323-141811530Exon17: 71 residues, 141817497-141817705Exon18: 89 residues, 141819545-141819807Exon19: 51 residues, 141820218-141820367Exon20: 2 residues, -Jump to Q6ZT07_HUMANExon1: 563 residues, 141761386-141763074Exon2: 53 residues, 141763368-141763521Exon3: 36 residues, 141764719-141764823Exon4: 27 residues, 141764917-141764992Exon5: 31 residues, 141768044-141768131Exon6: 24 residues, 141768903-141768969Exon7: 82 residues, 141774551-141774792Exon8: 25 residues, 141779689-141779758Exon9: 35 residues, 141779933-141780032Exon10: 45 residues, 141797700-141797830Exon11: 97 residues, 141798130-141798416Exon12: 41 residues, 141800191-141800309Exon13: 73 residues, 141802496-141802711Exon14: 52 residues, 141809520-141809671Exon15: 59 residues, 141810237-141810408Exon16: 71 residues, 141811323-141811530Exon17: 71 residues, 141817497-141817705Exon18: 89 residues, 141819545-141819807Exon19: 78 residues, 141820218-141820447Exon20: 41 residues, 141826947-141827066Exon21: 39 residues, 141842107-141842218Exon22: 136 residues, 141896519-141896921Exon23: 2 residues, -Jump to Q6ZT07_HUMANExon1: 712 residues, 141761388-141763521Exon2: 36 residues, 141764719-141764823Exon3: 27 residues, 141764917-141764992Exon4: 31 residues, 141768044-141768131Exon5: 24 residues, 141768903-141768969Exon6: 82 residues, 141774551-141774792Exon7: 25 residues, 141779689-141779758Exon8: 35 residues, 141779933-141780032Exon9: 45 residues, 141797700-141797830Exon10: 97 residues, 141798130-141798416Exon11: 41 residues, 141800191-141800309Exon12: 73 residues, 141802496-141802711Exon13: 52 residues, 141809520-141809671Exon14: 59 residues, 141810237-141810408Exon15: 71 residues, 141811323-141811530Exon16: 71 residues, 141817497-141817705Exon17: 89 residues, 141819545-141819807Exon18: 78 residues, 141820218-141820447Exon19: 41 residues, 141826947-141827066Exon20: 39 residues, 141842107-141842218Exon21: 70 residues, 141896519-141896724Exon22: 2 residues, -Jump to Q6ZT07_HUMAN  
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