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1Q6ZN35_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein flj16467.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005524 ATP binding (IEA)
0000166 nucleotide binding (IEA)
0004672 protein kinase activity (IEA)
0004872 receptor activity (IEA)
0006468 protein amino acid phosphorylation (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein kinases comprise a large family of enzymes that mediate the response of eukaryotic cells to external stimuli by phosphorylation of hydroxyamino acids. The enzymes fall into two broad classes.haracterised with respect to substrate specificity: serine/threonine specific and tyrosine specific . Tyrosine phosphorylating activity was originally detected in two viral transforming proteins .ut many retroviral transforming proteins and their cellular counterparts have since been shown to possess such activity. The growth factor receptors.hich are activated by ligand binding.nd theinsulin-related peptide receptor.re also family members.
  IPR001245:Tyrosine protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR001245:Pkinase_Tyr 
Evalue:-9.236572265625 
Location:42-66
SequencesProtein: Q6ZN35_HUMAN (170 aa)
mRNA: AK131389
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 117 residues, 39638523-39638871Exon2: 63 residues, 39640616-39640800Exon3: 35 residues, 39641028-39641129Exon4: 59 residues, 39642037-39642208Exon5: 31 residues, 39643673-39643760Exon6: 40 residues, 39644515-39644631Exon7: 61 residues, 39646849-39647027Exon8: 50 residues, 39647706-39647852Exon9: 50 residues, 39648367-39648512Exon10: 45 residues, 39649516-39649646Exon11: 35 residues, 39649729-39649830Exon12: 34 residues, 39650093-39650189Exon13: 29 residues, 39650527-39650608Exon14: 33 residues, 39651084-39651177Exon15: 42 residues, 39651932-39652054Exon16: 38 residues, 39652491-39652601Exon17: 55 residues, 39652797-39652957Exon18: 47 residues, 39653168-39653305Exon19: 483 residues, 39657375-39658818Exon20: 2 residues, -Jump to TYRO3_HUMANExon1: 669 residues, 39656824-39658828Exon2: 2 residues, -Jump to Q6ZN35_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2879 39907605-39927630 ~-20K 12149(+)Loci: 4164 39927636-39973567 ~-46K 12151(SPTBN5)(-)Loci: 4165 40238191-40287794 ~-50K 12159(VPS39)(-)Loci: 2880 40438989-40491807 ~-53K 12167(CAPN3)(+)Loci: 2881 40575126-40612548 ~-37K 12175(SNAP23)(+)Loci: 2882 40655148-40752587 ~-97K 12179(+)Loci: 2878 39638523-39658828 ~-20K 12142(TYRO3)(+)Link out to UCSC