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1Q6NT89_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical loc388610.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
SequencesProtein: Q6NT89_HUMAN (227 aa)
mRNA: NM_001013642
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 303 residues, 27192784-27193690Exon2: 271 residues, 27198924-27199731Exon3: 2 residues, -Jump to Q6NT89_HUMAN  
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Loci Cluster (Details)Loci: 2494 27120810-27145474 ~-25K 818(NUDC)(+)Loci: 2495 27192784-27199731 ~-7K 822(+)Loci: 2496 27541099-27553008 ~-12K 833(SYTL1)(+)Loci: 3786 27604712-27689256 ~-85K 852(WASF2)(-)Loci: 2497 27972369-28023401 ~-51K 864(STX12)(+)Loci: 3787 28173405-28287718 ~-114K 879(EYA3)(-)Loci: 2493 27062219-27063534 ~-1K 814(SFN)(+)Link out to UCSC