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1Q6IPL7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionLoxl3 protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016020 membrane (IEA)
0005507 copper ion binding (IEA)
0004720 protein-lysine 6-oxidase activity (IEA)
0005044 scavenger receptor activity (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Lysyl oxidase () (LOX) is an extracellular copper-dependent enzyme that catalyzes the oxidative deamination of peptidyl lysine residues in precursors of various collagens and elastins.ielding alpha-aminoadipic-delta-semialdehyde. The deaminated lysines are then able to form semialdehyde cross-links.esulting in the formation of insoluble collagen and elastin fibres in the extracellular matrix .The active site of LOX resides towards the C terminus: this region also binds a single copper atom in an octahedral coordination complex involving at least 3 His residues . Four histidine residues are clustered in a central region of the enzyme. This region is thought to be involved in cooper-binding and is called the copper-talon .
  IPR001695:Lysyl oxidase
The egg peptide speract receptor is a transmembrane glycoprotein . Other members of this family include the macrophagescavenger receptor type I (a membrane glycoprotein implicated in the pathologicdeposition of cholesterol in arterial walls during artherogenesis).n enteropeptidaseand T-cell surface glycoprotein CD5 (may act as a receptor in regulating T-cellproliferation).
  IPR001190:Speract/scavenger receptor
IPR001695:Lysyl_oxidase 
Evalue:-174.200653076172 
Location:384-587IPR001190:SR 
Evalue:-50.3372421683184 
Location:162-262IPR001190:SR 
Evalue:-49.2291479883579 
Location:44-145IPR001190:SR 
Evalue:-36.8860566476932 
Location:272-380
SequencesProtein: Q6IPL7_HUMAN (608 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00280
  Level 3 annotation:
    
  Level 2 annotation:
    Arginine and proline metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 288 residues, 74613453-74614314Exon2: 39 residues, 74614516-74614628Exon3: 47 residues, 74614734-74614871Exon4: 40 residues, 74614950-74615066Exon5: 83 residues, 74615165-74615409Exon6: 56 residues, 74615926-74616089Exon7: 58 residues, 74616222-74616390Exon8: 53 residues, 74616630-74616785Exon9: 62 residues, 74616925-74617106Exon10: 75 residues, 74617343-74617563Exon11: 73 residues, 74630003-74630218Exon12: 56 residues, 74630819-74630983Exon13: 110 residues, 74632956-74633281Exon14: 22 residues, 74634510-74634570Exon15: 2 residues, -Jump to LOXL3_HUMANExon1: 184 residues, 74613764-74614314Exon2: 39 residues, 74614516-74614628Exon3: 47 residues, 74614734-74614871Exon4: 40 residues, 74614950-74615066Exon5: 83 residues, 74615165-74615409Exon6: 56 residues, 74615926-74616089Exon7: 58 residues, 74616222-74616390Exon8: 53 residues, 74616630-74616785Exon9: 62 residues, 74616925-74617106Exon10: 56 residues, 74630819-74630983Exon11: 110 residues, 74632956-74633281Exon12: 29 residues, 74634510-74634593Exon13: 2 residues, -Jump to Q6IPL7_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3171 73973600-74000287 ~-27K 20655(ACTG2)(+)Loci: 3172 74007460-74039594 ~-32K 20656(DGUOK)(+)Loci: 4449 74441789-74461472 ~-20K 20675(DCTN1)(-)Loci: 4450 74613453-74634593 ~-21K 20704(LOXL3)(-)Loci: 3170 73909654-73943518 ~-34K 20654(STAMBP)(+)Link out to UCSC