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1Q68CS5_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein dkfzp781l0846.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0045211 postsynaptic membrane (IEA)
0005230 extracellular ligand-gated ion channel acti... (IEA)
0004890 GABA-A receptor activity (IEA)
0005216 ion channel activity (IEA)
0030594 neurotransmitter receptor activity (IEA)
0006811 ion transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain . Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs.ncluding barbiturates.naesthetics and benzodiazepines (BZs) . The BZs are a diverse range of compounds.ncluding widely prescribed drugs.uch as librium and valium.nd their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes. GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels . Eight types of receptor subunit have been cloned.ith multiple subtypes within some classes: alpha 1-6.eta 1-4.amma 1-4.elta.psilon.i.ho 1-3 and theta . Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain.ontaining a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members.he large cytoplasmic loop displays the most divergence in terms of primary structure.he TM domains showing the highest level of sequence conservation .A cDNA encoding the human GABAA receptor beta 2 subunit has been cloned andsequenced . Expression of recombinant human GABAA receptors containingdifferent beta subunits (beta 1.eta 2 or beta 3) in both transfectedcells and Xenopus laevis oocytes.as revealed the influence of the beta subunit onthe pharmacology of the receptor. For a number of benzodiazepine bindingsite compounds. barbiturate.nd several neurosteroids.either theaffinity nor the efficacy of the compounds is influenced by the type ofbeta subunit present in the receptor molecule . These observationssuggest that the beta subunit does not significantly influence thebenzodiazepine.arbiturate.r steroid site pharmacologies of human GABAAreceptor subtypes .
  IPR002289:Gamma-aminobutyric-acid A receptor, beta subunit
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain . Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs.ncluding barbiturates.naesthetics and benzodiazepines (BZs) . The BZs are a diverse range of compounds.ncluding widely prescribed drugs.uch as librium and valium.nd their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes. GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels . Eight types of receptor subunit have been cloned.ith multiple subtypes within some classes: alpha 1-6.eta 1-4.amma 1-4.elta.psilon.i.ho 1-3 and theta . Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain.ontaining a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members.he large cytoplasmic loop displays the most divergence in terms of primary structure.he TM domains showing the highest level of sequence conservation .
  IPR006028:Gamma-aminobutyric acid A receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006202:Neur_chan_LBD 
Evalue:-71.6382751464844 
Location:93-299IPR006029:Neur_chan_memb 
Evalue:-70.259635925293 
Location:306-524
SequencesProtein: Q68CS5_HUMAN (529 aa)
mRNA: CR749803 NM_021912
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05183
  Level 3 annotation:
    gamma-aminobutyric acid (GABA) A receptor, beta 3
  Level 2 annotation:
    Neuroactive ligand-receptor interaction
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1529 residues, 24339788-24344374Exon2: 83 residues, 24357171-24357416Exon3: 53 residues, 24363820-24363973Exon4: 48 residues, 24376558-24376696Exon5: 29 residues, 24379571-24379654Exon6: 75 residues, 24417553-24417774Exon7: 24 residues, 24568641-24568709Exon8: 32 residues, 24568920-24569012Exon9: 76 residues, 24569122-24569344Exon10: 2 residues, -Jump to GBRB3_HUMANExon1: 1529 residues, 24339788-24344374Exon2: 83 residues, 24357171-24357416Exon3: 53 residues, 24363820-24363973Exon4: 48 residues, 24376558-24376696Exon5: 29 residues, 24379571-24379654Exon6: 75 residues, 24417553-24417774Exon7: 24 residues, 24568641-24568709Exon8: 32 residues, 24568920-24569012Exon9: 47 residues, 24569884-24570020Exon10: 2 residues, -Jump to Q68CS5_HUMANExon1: 1528 residues, 24339792-24344374Exon2: 83 residues, 24357171-24357416Exon3: 53 residues, 24363820-24363973Exon4: 48 residues, 24376558-24376696Exon5: 29 residues, 24379571-24379654Exon6: 75 residues, 24417553-24417774Exon7: 24 residues, 24568641-24568709Exon8: 32 residues, 24568920-24569012Exon9: 18 residues, 24612606-24612654Exon10: 103 residues, 24767129-24767432Exon11: 2 residues, -Jump to Q68CS5_HUMAN  
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Loci Cluster (Details)Loci: 2867 24663150-24776749 ~-114K 11961(GABRA5)(+)Loci: 4159 24339788-24767432 ~-428K 11958(GABRB3)(-)Link out to UCSC