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1Q5VUG2_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionThioesterase, adipose associated, isoform bfit2.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003824 catalytic activity (IEA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
START (StAR-related lipid-transfer) is a lipid-binding domain in StAR.D-ZIP and signalling proteins . StAR (Steroidogenic Acute Regulatory protein) is a mitochondrial protein that is synthesised in response to luteinising hormone stimulation . Expression of the protein in the absence of hormone stimulation is sufficient to induce steroid production.uggesting that this protein is required in the acute regulation of steroidogenesis. Representatives of the START domain family havebeen shown to bind different ligands such as sterols (StAR protein) andphosphatidylcholine (PC-TP). Ligand binding by the START domain can alsoregulate the activities of other domains that co-occur with the START domainin multidomain proteins such as Rho-gap.he homeodomain.nd the thioesterase domain . The crystal structure of START domain of human MLN64 shows analpha/beta fold built around an U-shaped incomplete beta-barrel. Mostimportantly.he interior of the protein encompasses a 26 x 12 x 11 Angstromshydrophobic tunnel that is apparently large enough to bind a singlecholesterol molecule . The START domain structure revealed an unexpectedsimilarity to that of the birch pollen allergen Bet v 1 and to bacterialpolyketide cyclases/aromatases .
  IPR002913:Lipid-binding START
This family contains a wide variety of enzymes.rincipally thioesterases. This family includes 4HBT () which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate.hey also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.
  IPR006683:Thioesterase superfamily
IPR002913:START 
Evalue:-42.6575775146484 
Location:384-576IPR006683:4HBT 
Evalue:-12 
Location:234-311IPR006683:4HBT 
Evalue:-6.38721609115601 
Location:67-133
SequencesProtein: Q5VUG2_HUMAN (594 aa)
mRNA: NM_147161
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01076
  Level 3 annotation:
    
  Level 2 annotation:
    Limonene and pinene degradation
    Benzoate degradation via CoA ligation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 54786488-54786603Exon2: 71 residues, 54822915-54823123Exon3: 25 residues, 54824095-54824165Exon4: 22 residues, 54830806-54830867Exon5: 35 residues, 54832201-54832300Exon6: 47 residues, 54832816-54832952Exon7: 54 residues, 54835519-54835676Exon8: 42 residues, 54837556-54837676Exon9: 50 residues, 54839529-54839674Exon10: 20 residues, 54840929-54840985Exon11: 24 residues, 54842131-54842198Exon12: 30 residues, 54842606-54842690Exon13: 46 residues, 54843336-54843470Exon14: 46 residues, 54845394-54845526Exon15: 44 residues, 54846202-54846329Exon16: 53 residues, 54868994-54869147Exon17: 21 residues, 54872948-54873005Exon18: 2 residues, -Jump to ACO11_HUMANExon1: 39 residues, 54786488-54786603Exon2: 71 residues, 54822915-54823123Exon3: 25 residues, 54824095-54824165Exon4: 22 residues, 54830806-54830867Exon5: 35 residues, 54832201-54832300Exon6: 47 residues, 54832816-54832952Exon7: 54 residues, 54835519-54835676Exon8: 42 residues, 54837556-54837676Exon9: 50 residues, 54839529-54839674Exon10: 20 residues, 54840929-54840985Exon11: 24 residues, 54842131-54842198Exon12: 30 residues, 54842606-54842690Exon13: 46 residues, 54843336-54843470Exon14: 46 residues, 54845394-54845526Exon15: 44 residues, 54846202-54846329Exon16: 459 residues, 54847217-54848588Exon17: 2 residues, -Jump to Q5VUG2_HUMAN  
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Loci Cluster (Details)Loci: 3805 55087887-55125493 ~-38K 1573(DHCR24)(-)Loci: 2521 55277807-55303111 ~-25K 1577(PCSK9)(+)Loci: 2520 54786488-54873005 ~-87K 1560(ACOT11)(+)Link out to UCSC