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1Q5TMC1_9CHOR*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionNadh dehydrogenase subunit 5.
SpeciesEpigonichthys maldivensis (NCBI taxonomy ID: 231028)
GO0019866 inner membrane (IEA)
0016021 integral to membrane (IEA)
0005739 mitochondrion (IEA)
0008137 NADH dehydrogenase (ubiquinone) activity (IEA)
0016491 oxidoreductase activity (IEA)
0042773 ATP synthesis coupled electron transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in the NADH:ubiquinone oxidoreductase (complex I) which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane .
  IPR001750:NADH/Ubiquinone/plastoquinone (complex I)
This entry represents the C-terminal region of several NADH dehydrogenase subunit 5 proteins and is found in conjunction with and .
  IPR010934:NADH dehydrogenase subunit 5, C-terminal
This domain represents an N-terminal extension of . It contains NADH-Ubiquinone chain 5 and eubacterial chain L; these are found in the NADH:ubiquinone oxidoreductase (complex I) which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane .
  IPR001516:NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal
Mitochondrial NADH dehydrogenase subunit 5 (ND5) is an integral inner membrane protein. The protein is part of the NADH-ubiquinone oxidoreductase (complex I).hich catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane : NADH + ubiquinone = NAD(+) + ubiquinol In chloroplasts.his reaction is: NADH + plastoquinone = NAD(+) + plastoquinol. Defects in the ND5 gene are one of the causes of Lebers hereditary optic neuropathy. maternally inherited disease resulting in acute bilateral blindness due to retinal degeneration.redominantly in young men . Cardiac conduction defects and neurological defects have also been described.esulting in optic nerve degeneration and cardiac dysrhythmia . The clinical manifestations of this disease are thought to be the product of an overall decrease in mitochondrial energy production.ather than the result of a defect in a specific mitochondrial enzyme .
  IPR003916:NADH-ubiquinone oxidoreductase, chain 5
NADH-plastoquinone oxidoreductase chain 5 is part of the NADH-ubiquinone oxidoreductase (complex I).hich catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane : NADH + ubiquinone = NAD(+) + ubiquinol
  IPR003945:NADH-plastoquinone oxidoreductase, chain 5
IPR001750:Oxidored_q1 
Evalue:-99.0132293701172 
Location:127-408IPR010934:NADH5_C 
Evalue:-36.2441253662109 
Location:414-594IPR001516:Oxidored_q1_N 
Evalue:-16.1366767883301 
Location:55-116
SequencesProtein: Q5TMC1_9CHOR (597 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK03883
  Level 3 annotation:
    NADH dehydrogenase I subunit 5
  Level 2 annotation:
    Oxidative phosphorylation
Family_id: 53 NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5) (Fragment). 
Cross Links
Ensembl familyNot mapped to Ensembl families
Protein InteractionNot mapped to Bind and PPID
PDBNo similar entries in PDB
ModBaseLink out to the theoretical structure model
OMIMNot mapped to OMIM
PTMLink out to dbPTM
Gene-centric linksGEO: Expression
dbSNP: Signle Nucleotide Polymorphism
Reference
1J. Mol. Evol. 60:526-537(2005) Evolution of the mitochondrial genome in cephalochordata as inferred from complete nucleotide sequences from two epigonichthys species.

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