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1Q5STL7_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionGamma-aminobutyric acid (gaba) b receptor, 1 (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016020 membrane (IEA)
0004965 GABA-B receptor activity (IEA)
0004872 receptor activity (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.GABA is the principal inhibitory neurotransmitterin the brain.nd signals through ionotropic (GABA(A)/GABA(C)) andmetabotropic (GABA(B)) receptor systems. The GABA(B) receptors havebeen cloned.nd photoaffinity labelling experiments suggest that theycorrespond to two highly conserved receptor forms in the vertebrate nervoussystem .GABA(B) receptors are involved in the fine tuning of inhibitory synaptictransmission . Presynaptic receptors inhibit neurotransmitter release bydown-regulating high-voltage activated Ca2+ channels.hile postsynapticreceptors decrease neuronal excitability by activating a prominent inwardlyrectifying K+ (Kir) conductance that underlies the late inhibitory postsynaptic potentials . GABA(B) receptors negatively couple to adenylylcyclase and show sequence similarity to the metabotropic receptors for theexcitatory neurotransmitter L-glutamate.
  IPR002455:Metabotropic gamma-aminobutyric acid receptor, type B
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
IPR000337:7tm_3 
Evalue:-51.4202156066895 
Location:1-152
SequencesProtein: Q5STL7_HUMAN (162 aa)
mRNA: NM_021903 NM_021904
Local Annotation
Synapse Ontology
translating calcium signal into the corresponding biological event. Calcium may come from outside of the cell or subcelluar organelle to increase the cytosolic concentration.
sdb:0218 calcium sigal  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 55 residues, 1050579-1050740Exon19: 9 residues, 1052180-1052201Exon20: 64 residues, 1053551-1053737Exon21: 70 residues, 1054489-1054693Exon22: 30 residues, 1055394-1055479Exon23: 80 residues, 1055943-1056177Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 55 residues, 1050579-1050740Exon19: 9 residues, 1052180-1052201Exon20: 70 residues, 1054489-1054693Exon21: 30 residues, 1055394-1055479Exon22: 80 residues, 1055943-1056177Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 163 residues, 1050579-1051064Exon19: 2 residues, -Jump to Q5STL7_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 55 residues, 852541-852702Exon19: 9 residues, 854142-854163Exon20: 64 residues, 855513-855699Exon21: 70 residues, 856451-856655Exon22: 30 residues, 857356-857441Exon23: 80 residues, 857905-858139Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 55 residues, 852541-852702Exon19: 9 residues, 854142-854163Exon20: 70 residues, 856451-856655Exon21: 30 residues, 857356-857441Exon22: 80 residues, 857905-858139Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 163 residues, 852541-853026Exon19: 2 residues, -Jump to Q5STL7_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 55 residues, 29703241-29703402Exon19: 9 residues, 29704842-29704863Exon20: 64 residues, 29706213-29706399Exon21: 70 residues, 29707151-29707355Exon22: 30 residues, 29708056-29708141Exon23: 80 residues, 29708605-29708839Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 55 residues, 29703241-29703402Exon19: 9 residues, 29704842-29704863Exon20: 70 residues, 29707151-29707355Exon21: 30 residues, 29708056-29708141Exon22: 80 residues, 29708605-29708839Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 163 residues, 29703241-29703726Exon19: 2 residues, -Jump to Q5STL7_HUMAN  
Loci Cluster (Details)Loci: 3568 1080116-1095456 ~-15K 32266(MOG)(+)Loci: 4846 1569907-1577353 ~-7K 32295(TRIM10)(-)Loci: 3569 1743552-1760022 ~-16K 32299(+)Loci: 4847 2116160-2131531 ~-15K 32327(MDC1)(-)Loci: 3570 2136731-2141768 ~-5K 32330(TUBB2)(+)Loci: 3571 2300931-2316538 ~-16K 32336(DDR1)(+)Loci: 4848 2583391-2589717 ~-6K 32358(POU5F1)(-)Loci: 3572 2942907-2944177 ~-1K 32370(MCCD1)(+)Loci: 3573 2989472-2992233 ~-3K 32379(TNF)(+)Loci: 3574 3034720-3051660 ~-17K 32394(BAT2)(+)Loci: 4849 3100861-3117213 ~-16K 32408(BAT5)(-)Loci: 4850 3144482-3150469 ~-6K 32420(CLIC1)(-)Loci: 4851 3273206-3276937 ~-4K 32436(NEU1)(-)Loci: 4852 3366127-3373127 ~-7K 32450(RDBP)(-)Loci: 4853 3416089-3484322 ~-68K 32465(TNXB)(-)Loci: 4854 3490215-3503197 ~-13K 32467(CREBL1)(-)Loci: 4855 3569805-3599027 ~-29K 32497(NOTCH4)(-)Loci: 4845 1025321-1056177 ~-31K 32256(GABBR1)(-)Link out to UCSC  
Loci: 3576 882132-897414 ~-15K 32584(MOG)(+)Loci: 4860 1368158-1375605 ~-7K 32610(TRIM10)(-)Loci: 3577 1541880-1558353 ~-16K 32616(+)Loci: 4861 1914463-1929833 ~-15K 32644(MDC1)(-)Loci: 3578 1935034-1940072 ~-5K 32647(TUBB2)(+)Loci: 3579 2099260-2114867 ~-16K 32653(DDR1)(+)Loci: 4862 2381927-2388269 ~-6K 32673(POU5F1)(-)Loci: 3580 2744366-2745636 ~-1K 32685(MCCD1)(+)Loci: 3581 2790934-2793697 ~-3K 32694(TNF)(+)Loci: 3582 2836184-2853121 ~-17K 32708(BAT2)(+)Loci: 4863 2902325-2918686 ~-16K 32722(BAT5)(-)Loci: 4864 2945936-2951926 ~-6K 32734(CLIC1)(-)Loci: 4865 3074690-3078421 ~-4K 32743(NEU1)(-)Loci: 4866 3167604-3174600 ~-7K 32757(RDBP)(-)Loci: 4867 3377585-3406812 ~-29K 32798(NOTCH4)(-)Loci: 4859 827283-858139 ~-31K 32580(GABBR1)(-)Link out to UCSC  
Loci: 3523 29732787-29748126 ~-15K 30583(MOG)(+)Loci: 4776 29677984-29708839 ~-31K 30576(GABBR1)(-)Link out to UCSC