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1Q5JR65_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionAnkyrin 3, node of ranvier (ankyrin g).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IEA)
0007165 signal transduction (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a domain of unknown function.resent in ZO-1 and Unc5-like netrin receptors. It is also found in different variants of ankyrin.hich are responsible for attaching integral membrane proteins to cytoskeletal elements.
  IPR000906:ZU5
The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD is related in sequence and structure to the death effector domain (DED.ee ) and the caspase recruitment domain (CARD.ee ).hich work in similar pathways and show similar interaction properties . DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins . Within these proteins.he DD domains can be found in combination with other domains.ncluding: CARDs.EDs.nkyrin repeats ().aspase-like folds.inase domains.eucine zippers ().eucine-rich repeats (LRR) ().IR domains ().nd ZU5 domains () .Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.hich typically involves interactions with TNF (tumour necrosis factor) cytokine receptors . In humans.ight of the over 30 known TNF receptors contain DD in their cytoplasmic tails; several of these TNF receptors use caspase activation as a signalling mechanism. The DD mediates self-association of these receptors.hus giving the signal to downstream events that lead to apoptosis. Other DD-containing proteins.uch as ankyrin.yD88 and pelle.re probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity.ommunicating with Toll family receptors through bipartite adapter proteins such as MyD88 .
  IPR000488:Death
The death domain (DD) is a conserved region of about 80 residues found on death receptors.nd which is required for death signalling.s well as a variety of non-apoptotic functions . Proteins containing this domain include the low affinity neurotrophin receptor p73.as.ADD (Fas-associated death domain protein).NF-1 (tumour necrosis factor receptor-1).elle protein kinase.nd the Tube adaptor protein .The induction of apoptosis also relies on the presence of a second domain.alled the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death.ncluding both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways . Proteins containing this domain include FADD (DED N-terminal.D C-terminal).EA-15 (phosphoproteins enriched in astrocytes 15kDa).aspases and FLIP.The induction of apoptosis results in the activation of caspases. family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example.he DED of FADD recruits two DED-containing caspases.aspase-8 and caspase-10.o form the death-inducing signal complex.hich initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis . Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd.PAF-1 (apoptotic protease activating factor 1).rocaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold.ith greek key topology and an internal psuedo two-fold symmetry. However.espite their overall similarity in topology.ach domain forms specialised interactions.ypically only with members of its own subfamily.or example DED with DED.Please be aware that some of the proteins hit by the SSF signature may be false positives.
  IPR011029:DEATH-like
IPR000906:ZU5 
Evalue:-69.3872146606445 
Location:116-220IPR000488:DEATH 
Evalue:-32.4089353929735 
Location:601-695
SequencesProtein: Q5JR65_HUMAN (1001 aa)
mRNA: NM_001149
Local Annotation
Synapse Ontology
The gaps (approximately 1 micrometer wide) formed between myelin sheath cells along the axons are called Nodes of Ranvier.
sdb:0242 Ranvier node  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 476 residues, 61458165-61459590Exon2: 31 residues, 61472435-61472523Exon3: 128 residues, 61485421-61485800Exon4: 32 residues, 61489103-61489194Exon5: 50 residues, 61492874-61493018Exon6: 46 residues, 61493920-61494052Exon7: 27 residues, 61497698-61497773Exon8: 2606 residues, 61498400-61506212Exon9: 29 residues, 61510300-61510382Exon10: 11 residues, 61511913-61511940Exon11: 43 residues, 61512378-61512501Exon12: 44 residues, 61513255-61513381Exon13: 78 residues, 61514365-61514594Exon14: 34 residues, 61514920-61515017Exon15: 71 residues, 61516440-61516648Exon16: 72 residues, 61517910-61518122Exon17: 53 residues, 61535668-61535823Exon18: 77 residues, 61538593-61538818Exon19: 37 residues, 61543988-61544095Exon20: 36 residues, 61564034-61564137Exon21: 43 residues, 61568727-61568851Exon22: 23 residues, 61596354-61596417Exon23: 26 residues, 61596587-61596660Exon24: 34 residues, 61602071-61602167Exon25: 35 residues, 61602663-61602762Exon26: 35 residues, 61602851-61602950Exon27: 35 residues, 61611092-61611191Exon28: 68 residues, 61616478-61616676Exon29: 35 residues, 61625908-61626007Exon30: 35 residues, 61626290-61626389Exon31: 68 residues, 61628103-61628301Exon32: 35 residues, 61629892-61629991Exon33: 35 residues, 61632765-61632864Exon34: 35 residues, 61635555-61635654Exon35: 68 residues, 61637799-61637997Exon36: 35 residues, 61643175-61643274Exon37: 35 residues, 61664451-61664550Exon38: 35 residues, 61691622-61691721Exon39: 64 residues, 61693598-61693784Exon40: 35 residues, 61699894-61699993Exon41: 35 residues, 61708537-61708636Exon42: 35 residues, 61708813-61708912Exon43: 36 residues, 61709301-61709403Exon44: 104 residues, 61819188-61819494Exon45: 2 residues, -Jump to ANK3_HUMANExon1: 476 residues, 61458165-61459590Exon2: 31 residues, 61472435-61472523Exon3: 128 residues, 61485421-61485800Exon4: 32 residues, 61489103-61489194Exon5: 105 residues, 61489461-61489770Exon6: 50 residues, 61492874-61493018Exon7: 46 residues, 61493920-61494052Exon8: 27 residues, 61497698-61497773Exon9: 29 residues, 61510300-61510382Exon10: 43 residues, 61512378-61512501Exon11: 44 residues, 61513255-61513381Exon12: 78 residues, 61514365-61514594Exon13: 34 residues, 61514920-61515017Exon14: 71 residues, 61516440-61516648Exon15: 72 residues, 61517910-61518122Exon16: 53 residues, 61535668-61535823Exon17: 77 residues, 61538593-61538818Exon18: 37 residues, 61543988-61544095Exon19: 36 residues, 61564034-61564137Exon20: 43 residues, 61568727-61568851Exon21: 214 residues, 61570115-61570752Exon22: 2 residues, -Jump to Q5JR65_HUMAN  
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