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1Q5JPC9_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein dkfzp667h216.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Fibronectins are multi-domain glycoproteins found in a soluble form in plasma.nd in an insoluble form in loose connective tissue and basement membranes . They contain multiple copies of 3 repeat regions (types I.I and III).hich bind to a variety of substances including heparin.ollagen.NA.ctin.ibrin and fibronectin receptors on cell surfaces. The wide variety of these substances means that fibronectins are involved in a number of important functions: e.g..ound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis . The role of fibronectin in cell differentiation is demonstrated by the marked reduction in the expression of its gene when neoplastic transformation occurs. Cell attachment has been found to be mediated by the binding of the tetrapeptide RGDS to integrins on the cell surface .lthough related sequences can also display cell adhesion activity.Plasma fibronectin occurs as a dimer of 2 different subunits.inked together by 2 disulphide bonds near the C-terminus. The difference in the 2 chains occurs in the type III repeat region and is caused by alternative splicing of the mRNA from one gene . The observation that.n a given protein.n individual repeat of one of the 3 types (e.g..he first FnIII repeat) shows much less similarity to its subsequent tandem repeats within that protein than to its equivalent repeat between fibronectins from other species.as suggested that the repeating structure of fibronectin arose at an early stage of evolution. It also seems to suggest that the structure is subject to high selective pressure .The fibronectin type III repeat region is an approximately 100 amino acid domain.ifferent tandem repeats of which contain binding sites for DNA.eparin and the cell surface . The superfamily of sequences believed to contain FnIII repeats represents 45 different families.he majority of which are involved in cell surface binding in some manner.r are receptor protein tyrosine kinases.r cytokine receptors.
  IPR003961:Fibronectin, type III
Fibronectin is composed of three repeating structural motifs.f which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module.hich is the only fibronectin module to possess an integrin binding RGD motif.onsists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG.espectively.hich fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008957:Fibronectin, type III-like fold
IPR003961:fn3 
Evalue:-2.32790207862854 
Location:121-211
SequencesProtein: Q5JPC9_HUMAN (1005 aa)
mRNA: AL833204
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 425 residues, 101950870-101952144Exon2: 43 residues, 101953085-101953208Exon3: 56 residues, 101954320-101954482Exon4: 12 residues, 101955352-101955382Exon5: 28 residues, 101956145-101956225Exon6: 38 residues, 101967374-101967483Exon7: 72 residues, 101972276-101972486Exon8: 25 residues, 101976138-101976207Exon9: 45 residues, 101976740-101976869Exon10: 33 residues, 101979817-101979910Exon11: 28 residues, 101981665-101981743Exon12: 23 residues, 101990987-101991050Exon13: 28 residues, 101994224-101994302Exon14: 29 residues, 101996456-101996537Exon15: 22 residues, 101997942-101998002Exon16: 27 residues, 102006325-102006400Exon17: 27 residues, 102009694-102009769Exon18: 27 residues, 102047905-102047980Exon19: 26 residues, 102049135-102049207Exon20: 27 residues, 102050334-102050409Exon21: 27 residues, 102051578-102051653Exon22: 27 residues, 102052193-102052268Exon23: 24 residues, 102053408-102053474Exon24: 27 residues, 102063844-102063919Exon25: 27 residues, 102066366-102066441Exon26: 28 residues, 102068412-102068490Exon27: 33 residues, 102076374-102076467Exon28: 26 residues, 102077041-102077113Exon29: 18 residues, 102078045-102078094Exon30: 19 residues, 102087069-102087122Exon31: 62 residues, 102087675-102087857Exon32: 46 residues, 102100295-102100428Exon33: 25 residues, 102104151-102104220Exon34: 62 residues, 102127835-102128015Exon35: 57 residues, 102194839-102195004Exon36: 2 residues, -Jump to TARSH_HUMANExon1: 253 residues, 102017544-102018302Exon2: 22 residues, 102018969-102019029Exon3: 21 residues, 102020058-102020115Exon4: 30 residues, 102021753-102021837Exon5: 22 residues, 102022587-102022647Exon6: 30 residues, 102024122-102024206Exon7: 21 residues, 102024991-102025048Exon8: 30 residues, 102026391-102026475Exon9: 31 residues, 102033797-102033884Exon10: 13 residues, 102034658-102034691Exon11: 32 residues, 102036217-102036307Exon12: 22 residues, 102037134-102037194Exon13: 18 residues, 102038657-102038705Exon14: 27 residues, 102039743-102039818Exon15: 23 residues, 102039935-102039998Exon16: 18 residues, 102041102-102041150Exon17: 33 residues, 102041605-102041698Exon18: 15 residues, 102042353-102042392Exon19: 16 residues, 102043531-102043573Exon20: 27 residues, 102047905-102047980Exon21: 26 residues, 102049135-102049207Exon22: 27 residues, 102050334-102050409Exon23: 27 residues, 102051578-102051653Exon24: 27 residues, 102052193-102052268Exon25: 24 residues, 102053408-102053474Exon26: 27 residues, 102063844-102063919Exon27: 26 residues, 102064371-102064443Exon28: 27 residues, 102065535-102065610Exon29: 27 residues, 102066366-102066441Exon30: 28 residues, 102068412-102068490Exon31: 33 residues, 102076374-102076467Exon32: 26 residues, 102077041-102077113Exon33: 18 residues, 102078045-102078094Exon34: 19 residues, 102087069-102087122Exon35: 62 residues, 102087675-102087857Exon36: 46 residues, 102100295-102100428Exon37: 25 residues, 102104151-102104220Exon38: 62 residues, 102127835-102128015Exon39: 51 residues, 102194839-102194987Exon40: 2 residues, -Jump to Q5JPC9_HUMAN  
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