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1Q59GS6_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionDiacylglycerol kinase, gamma 90kda variant (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (IEA)
0004143 diacylglycerol kinase activity (IEA)
0007242 intracellular signaling cascade (IEA)
0007205 protein kinase C activation (IEA)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases.ollectively known as protein kinase C (PKC) . Phorbol esters can directly stimulate PKC. The N-terminal region of PKC.nown as been shown to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain.hich is about 50 amino-acid residues long.nd which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.
  IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding
Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The DAGkinase domain is assumed to be an accessory domain. Upon cell stimulation.AG kinase convertsDAG into phosphatidate.nitiating the resynthesis of phosphatidylinositols and attenuatingprotein kinase C activity. It catalyzes the reaction: ATP + 1.-diacylglycerol = ADP +1.-diacylglycerol 3-phosphate. The enzyme is stimulated by calcium and phosphatidylserineand phosphorylated by protein kinase C. This domain is always associated with .
  IPR000756:Diacylglycerol kinase accessory region
Diacylglycerol kinase (DGK. phosphorylates diacylglycerol (DAG) to yield phosphatidic acid. This enzyme initiates resynthesis of phosphoinositides consumed by phospholipase C during cellular signal transduction. Mammalian DGK consists of nine isozymes encoded by separate genes . In addition to PKC-like zinc fingers and catalytic regions commonly conserved in all DGKs.hese isozymes contain a variety of regulatory domains of known and/or predicted functions. The mammalian isozymes are named according to the order of their cDNA cloning and are subdivided into five groups based on their characteristic structural features. Each DGK isozyme is a critical downstream component of a DAG-dependent signaling system. This domain is usually associated with an accessory domain (see ).
  IPR001206:Diacylglycerol kinase, catalytic region
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
SequencesProtein: Q59GS6_HUMAN (605 aa)
mRNA: BC112363
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK00901
  Level 3 annotation:
    diacylglycerol kinase
  Level 2 annotation:
    Glycerolipid metabolism
    Glycerophospholipid metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 245 residues, 187349939-187350671Exon2: 22 residues, 187362085-187362146Exon3: 42 residues, 187365380-187365501Exon4: 61 residues, 187388684-187388862Exon5: 32 residues, 187412277-187412368Exon6: 23 residues, 187442986-187443051Exon7: 55 residues, 187452241-187452402Exon8: 32 residues, 187453575-187453665Exon9: 30 residues, 187458336-187458422Exon10: 27 residues, 187460921-187460996Exon11: 28 residues, 187462181-187462261Exon12: 22 residues, 187465729-187465789Exon13: 33 residues, 187468167-187468260Exon14: 31 residues, 187472737-187472826Exon15: 41 residues, 187476029-187476147Exon16: 43 residues, 187480333-187480456Exon17: 27 residues, 187481152-187481227Exon18: 18 residues, 187485142-187485192Exon19: 59 residues, 187489192-187489363Exon20: 23 residues, 187497903-187497966Exon21: 57 residues, 187498546-187498712Exon22: 27 residues, 187507383-187507460Exon23: 107 residues, 187520875-187521190Exon24: 2 residues, -Jump to Q59GS6_HUMAN  
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Loci Cluster (Details)Loci: 4653 187349939-187521190 ~-171K 26985(-)Loci: 3393 187813580-187821799 ~-8K 26990(AHSG)(+)Loci: 4652 187117235-187138450 ~-21K 26980(SFRS10)(-)Link out to UCSC