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1Q53TY4_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionCsmd2 protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The CUB domain is an extracellular domain of approximately 110 residues which is found in functionally diverse.ostly developmentally regulated proteins .nd in peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Almost all CUB domains contain four conserved cysteines which probably form two disulphide bridges (C1-C2.3-C4). The structure of the CUB domain has been predicted to be a beta-barrel similar to that of immunoglobulins. Proteins that have been found to contain the CUB domain include mammalian complement subcomponents C1s/C1r.hich form the calcium-dependent complex C1.he first component of the classical pathway of the complement system; hamster serine protease Casp.hich degrades type I and IV collagen and fibronectin in the presence of calcium; mammalian complement-activating component of Ra-reactive factor (RARF). protease that cleaves the C4 component of complement; vertebrate enteropeptidase (). type II membrane protein of the intestinal brush border.hich activates trypsinogen; vertebrate bone morphogenic protein 1 (BMP-1). protein which induces cartilage and bone formation and expresses metalloendopeptidase activity; sea urchins blastula proteins BP10 and SpAN; Caenorhabditis elegans hypothetical proteins F42A10.8 and R151.5; neuropilin (A5 antigen). calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits; fibropellins I and III from sea urchin; mammalian hyaluronate-binding protein TSG-6 (or PS4). serum and growth factor induced protein; mammalian spermadhesins; and Xenopus embryonic protein UVS.2.hich is expressed during dorsoanterior development.
  IPR000859:CUB
Sushi domains are also known as Complement control protein (CCP) modules.r short consensus repeats (SCR).xist in a widevariety of complement and adhesion proteins. The structure is known for this domain.t is based on a beta-sandwich arrangement; oneface made up of three beta-strands hydrogen-bonded to form a triple-stranded region at itscentre and the other face formed from two separate beta-strands .CD21 (also called C3d receptor.R2.pstein Barr virus receptor or EBV-R) is the receptor for EBV and for C3d.3dg and iC3b. Complement components may activate B cells through CD21. CD21 is part of a large signal-transduction complex that also involves CD19.D81.nd Leu13. Some of the proteins in this group are responsible for the molecular basis of the blood group antigens.urface markers on the outside of the red blood cell membrane. Most of these markers are proteins.ut some are carbohydrates attached to lipids or proteins [Reid M.E..omas-Francis C. The Blood Group Antigen FactsBook Academic Press.ondon / San Diego.1997)]. Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a).r(a).s(a).c(a/b/c).d(a).ES(a/b).FC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and is associated with Kn(a/b).cC(a).l(a) and Yk(a) antigens.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR000436:Sushi/SCR/CCP
IPR000859:CUB 
Evalue:-44.0861854553223 
Location:1485-1590IPR000859:CUB 
Evalue:-35.3098030090332 
Location:792-897IPR000859:CUB 
Evalue:-33.8860566476932 
Location:618-726IPR000859:CUB 
Evalue:-33.5528411865234 
Location:445-553IPR000859:CUB 
Evalue:-32.8239087409443 
Location:1836-1944IPR000859:CUB 
Evalue:-32.5376014709473 
Location:2008-2113IPR000859:CUB 
Evalue:-29.3372421264648 
Location:242-343IPR000859:CUB 
Evalue:-28.698970004336 
Location:66-174IPR000859:CUB 
Evalue:-26.1487416512809 
Location:1311-1420IPR000859:CUB 
Evalue:-26.1191864013672 
Location:1138-1243IPR000859:CUB 
Evalue:-25.5686359405518 
Location:2180-2284IPR000859:CUB 
Evalue:-23.1611509092627 
Location:2354-2464IPR000859:CUB 
Evalue:-20.7212463990472 
Location:964-1074IPR000859:CUB 
Evalue:-19.3187587626244 
Location:1659-1767IPR000436:CCP 
Evalue:-14.7447274948967 
Location:2121-2176IPR000436:Sushi 
Evalue:-14.6989698410034 
Location:3156-3209IPR000436:Sushi 
Evalue:-14.0705814361572 
Location:2797-2850IPR000436:CCP 
Evalue:-13.9586073148418 
Location:2979-3032IPR000436:CCP 
Evalue:-13.8239087409443 
Location:2739-2792IPR000436:Sushi 
Evalue:-13.7695512771606 
Location:2855-2913IPR000436:CCP 
Evalue:-13.6575773191778 
Location:3275-3329IPR000436:Sushi 
Evalue:-13.4317979812622 
Location:2656-2709IPR000436:CCP 
Evalue:-12.8239087409443 
Location:2292-2349IPR000436:CCP 
Evalue:-12.7212463990472 
Location:561-614IPR000436:CCP 
Evalue:-12.537602002101 
Location:1251-1307IPR000436:CCP 
Evalue:-12.5086383061657 
Location:1079-1134IPR000436:CCP 
Evalue:-12.2291479883579 
Location:3214-3267IPR000436:CCP 
Evalue:-12.2076083105017 
Location:1949-2004IPR000436:CCP 
Evalue:-11.7695510786217 
Location:179-236IPR000436:CCP 
Evalue:-11.6382721639824 
Location:383-440IPR000436:CCP 
Evalue:-11.130768280269 
Location:2529-2586IPR000436:CCP 
Evalue:-10.431798275933 
Location:907-960IPR000436:CCP 
Evalue:-10 
Location:1598-1655IPR000436:CCP 
Evalue:-9.95860731484177 
Location:3096-3151IPR000436:CCP 
Evalue:-9.95860731484177 
Location:2918-2971IPR000436:CCP 
Evalue:-9.88605664769316 
Location:1775-1832IPR000436:Sushi 
Evalue:-9.6777811050415 
Location:3334-3389IPR000436:Sushi 
Evalue:-9.45593166351318 
Location:2591-2651IPR000436:CCP 
Evalue:-9.4089353929735 
Location:3037-3091IPR000436:CCP 
Evalue:-8.79588001734407 
Location:1425-1481IPR000436:CCP 
Evalue:-8.74472749489669 
Location:2466-2524IPR000436:Sushi 
Evalue:-8.16115093231201 
Location:731-788
SequencesProtein: Q53TY4_HUMAN (3631 aa)
mRNA: AB212622
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 853 residues, 33752199-33754757Exon2: 73 residues, 33757651-33757864Exon3: 48 residues, 33757998-33758137Exon4: 31 residues, 33759649-33759737Exon5: 39 residues, 33761493-33761606Exon6: 56 residues, 33763068-33763230Exon7: 23 residues, 33765382-33765445Exon8: 62 residues, 33771236-33771416Exon9: 39 residues, 33771982-33772094Exon10: 26 residues, 33775208-33775282Exon11: 60 residues, 33775622-33775796Exon12: 60 residues, 33778711-33778885Exon13: 62 residues, 33779316-33779496Exon14: 61 residues, 33780906-33781083Exon15: 63 residues, 33784223-33784406Exon16: 60 residues, 33788363-33788537Exon17: 65 residues, 33795920-33796109Exon18: 60 residues, 33797486-33797660Exon19: 85 residues, 33805779-33806028Exon20: 60 residues, 33807560-33807734Exon21: 67 residues, 33809718-33809913Exon22: 64 residues, 33810692-33810878Exon23: 65 residues, 33815482-33815671Exon24: 51 residues, 33818939-33819086Exon25: 65 residues, 33821828-33822017Exon26: 40 residues, 33824690-33824804Exon27: 29 residues, 33825274-33825355Exon28: 50 residues, 33839051-33839197Exon29: 61 residues, 33840555-33840733Exon30: 65 residues, 33843468-33843657Exon31: 72 residues, 33849227-33849437Exon32: 41 residues, 33852690-33852807Exon33: 25 residues, 33855092-33855162Exon34: 41 residues, 33855685-33855804Exon35: 37 residues, 33860353-33860458Exon36: 34 residues, 33861556-33861653Exon37: 43 residues, 33862705-33862830Exon38: 70 residues, 33863237-33863441Exon39: 34 residues, 33864672-33864768Exon40: 40 residues, 33871608-33871722Exon41: 41 residues, 33873400-33873517Exon42: 67 residues, 33874546-33874741Exon43: 64 residues, 33884834-33885022Exon44: 48 residues, 33890509-33890648Exon45: 66 residues, 33896132-33896324Exon46: 69 residues, 33901076-33901279Exon47: 44 residues, 33931116-33931243Exon48: 66 residues, 33936939-33937131Exon49: 54 residues, 33938703-33938860Exon50: 58 residues, 33947275-33947445Exon51: 65 residues, 33952773-33952962Exon52: 74 residues, 33954472-33954688Exon53: 41 residues, 33962383-33962500Exon54: 65 residues, 33962703-33962892Exon55: 64 residues, 33963536-33963724Exon56: 48 residues, 33964734-33964873Exon57: 67 residues, 33977327-33977522Exon58: 111 residues, 33981467-33981794Exon59: 63 residues, 34010756-34010939Exon60: 39 residues, 34026787-34026900Exon61: 36 residues, 34030610-34030714Exon62: 42 residues, 34048930-34049052Exon63: 43 residues, 34057900-34058025Exon64: 31 residues, 34058656-34058744Exon65: 28 residues, 34063884-34063962Exon66: 39 residues, 34085071-34085184Exon67: 71 residues, 34156281-34156489Exon68: 67 residues, 34173947-34174142Exon69: 39 residues, 34270781-34270894Exon70: 74 residues, 34327164-34327381Exon71: 123 residues, 34403098-34403462Exon72: 2 residues, -Jump to Q53TY4_HUMAN  
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