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1Q4G112_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionFlj40311 protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Heat shock factor (HSF) is a transcriptional activator of heat shock genes: it binds specifically to heat shock promoter elements.hich arepalindromic sequences rich with repetitive purine and pyrimidine motifs .Under normal conditions.SF is a homo-trimeric cytoplasmic protein.utheat shock activation results in relocalisation to the nucleus .Each HSF monomer contains one C-terminal and three N-terminal leucine zipperrepeats . Point mutations in these regions result in disruption ofcellular localisation.endering the protein constitutively nuclear .Two sequences flanking the N-terminal zippers fit the consensus of a bi-partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF.hese may then be unmasked.esulting in relocalisation of the protein to the nucleus . The DNA-binding componentof HSF lies to the N-terminus of the first NLS region.nd is referred toas the HSF domain.
  IPR000232:Heat shock factor (HSF)-type, DNA-binding
Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif.here the "wings".r loops.re small beta-sheets. The winged helix motif consists of two wings (W1.2).hree alpha helices (H1.2.3) and three beta-sheets (S1.2.3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 . The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA.hile the wings make different DNA contacts.ften with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain.ncluding transcriptional repressors such as biotin repressor.exA repressor and the arginine repressor ; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation.eat-shock transcription factor.nd the general transcription factors TFIIE and TFIIF . helicases such as RuvB that promotes branch migration at the Holliday junction.nd CDC6 in the pre-replication complex . endonucleases such as FokI and TnsA ; histones; and Mu transposase.here the flexible wing of the enhancer-binding domain is essential for efficient transposition .
  IPR011991:Winged helix repressor DNA-binding
IPR000232:HSF 
Evalue:-12.4559319556497 
Location:10-130
SequencesProtein: Q4G112_HUMAN (596 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 755 residues, 53852527-53854790Exon2: 61 residues, 53891127-53891305Exon3: 176 residues, 53895141-53895663Exon4: 33 residues, 53899244-53899339Exon5: 127 residues, 53912252-53912627Exon6: 222 residues, 53920084-53920744Exon7: 2 residues, -Jump to Q4G112_HUMAN  
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Loci Cluster (Details)Loci: 3025 53515797-53521810 ~-6K 16281(DLC2)(+)Loci: 4304 53733592-53760477 ~-27K 16290(BZRAP1)(-)Loci: 4305 53852527-53920744 ~-68K 16295(-)Loci: 4306 53952614-53964410 ~-12K 16299(-)Loci: 4303 53435861-53439592 ~-4K 16279(SFRS1)(-)Link out to UCSC