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1Q4G0X4_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical protein loc283219.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The N-terminal.ytoplasmic tetramerization domain (T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels . This domain is found in a subset of a larger group of proteins that obtain BTB/POZ domain.
  IPR003131:K+ channel tetramerisation
The BTB (for and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
SequencesProtein: Q4G0X4_HUMAN (260 aa)
mRNA: BC062331 NM_001029859
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1110 residues, 77559948-77563277Exon2: 17 residues, 77577266-77577312Exon3: 2 residues, -Jump to Q4G0X4_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 517 residues, 77562468-77564017Exon2: 2 residues, -Jump to Q4G0X4_HUMAN  
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Loci Cluster (Details)Loci: 3975 77457048-77468579 ~-12K 7475(NDUFC2)(-)Loci: 3976 77489638-77528343 ~-39K 7476(ALG8)(-)Loci: 3977 77559948-77577312 ~-17K 7479(-)Loci: 2695 77562468-77564017 ~-2K 7480(+)Loci: 3974 77004847-77026495 ~-22K 7463(CLNS1A)(-)Link out to UCSC