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1Q13127_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionRest protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0016564 transcriptional repressor activity (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR007087:zf-C2H2 
Evalue:-5.24412536621094 
Location:304-326IPR007087:zf-C2H2 
Evalue:-2.82390880584717 
Location:361-383IPR007087:zf-C2H2 
Evalue:-2.45593190193176 
Location:276-298IPR007087:ZnF_C2H2 
Evalue:-1.60205999132796 
Location:332-355IPR007087:ZnF_C2H2 
Evalue:-1.60205999132796 
Location:389-412IPR007087:ZnF_C2H2 
Evalue:-1.60205999132796 
Location:248-270IPR007087:zf-C2H2 
Evalue:-1.28399670124054 
Location:1060-1082IPR007087:ZnF_C2H2 
Evalue:-0.823908740944319 
Location:159-181IPR007087:ZnF_C2H2 
Evalue:0.491361693834273 
Location:216-238
SequencesProtein: Q13127_HUMAN (1097 aa)
mRNA: NM_005612
Local Annotation
Synapse Ontology
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK03610
  Level 3 annotation:
    septum site-determining protein MinC
  Level 2 annotation:
    Cell division
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 113 residues, 57468798-57469136Exon2: 304 residues, 57471552-57472459Exon3: 30 residues, 57480709-57480793Exon4: 779 residues, 57490763-57493096Exon5: 2 residues, -Jump to Q13127_HUMAN  
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