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0PWP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePWP2H
DescriptionPeriodic tryptophan protein 2 homolog.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004871 signal transducer activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in PWP2. member of the WD-repeat family of proteins.hich is an essential Saccharomyces cerevisiae protein involved in cell separation.
  IPR007190:Periodic tryptophan protein-associated region
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
Nitrous oxide (N2O) reductase () is a copper-containing enzyme that catalyses the two-electron reduction of the greenhouse gas N2O to N2 . N2O reductase has two domains.n N-terminal 7-bladed beta-propeller domain that contains the CuZ catalytic centre.nd a C-terminal domain with a cupredoxin fold that is homologous to the CuA domain of bovine cytochrome c oxidase (COXII).The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011045:Nitrous oxide reductase, N-terminal
IPR007190:PWP2 
Evalue:-72.4685211181641 
Location:765-882IPR001680:WD40 
Evalue:-12.32790184021 
Location:491-529IPR001680:WD40 
Evalue:-7.53760194778442 
Location:363-401IPR001680:WD40 
Evalue:-6.56863641738892 
Location:405-443IPR001680:WD40 
Evalue:-1.65757727622986 
Location:134-172IPR011045:N2O_reductase_N 
Evalue:0 
Location:537-637IPR011045:N2O_reductase_N 
Evalue:0 
Location:692-731IPR001680:WD40 
Evalue:0.176091259055681 
Location:177-216IPR001680:WD40 
Evalue:0.724275869600789 
Location:319-359IPR001680:WD40 
Evalue:1.25527250510331 
Location:86-123IPR001680:WD40 
Evalue:1.82607480270083 
Location:277-316IPR001680:WD40 
Evalue:1.92427928606188 
Location:446-487IPR001680:WD40 
Evalue:2.17609125905568 
Location:43-83
SequencesProtein: PWP2_HUMAN (919 aa)
mRNA: NM_005049
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 37 residues, 44351635-44351743Exon2: 39 residues, 44353292-44353405Exon3: 33 residues, 44358061-44358156Exon4: 35 residues, 44358487-44358587Exon5: 50 residues, 44358933-44359077Exon6: 47 residues, 44359572-44359708Exon7: 78 residues, 44359999-44360229Exon8: 50 residues, 44362128-44362272Exon9: 25 residues, 44363071-44363142Exon10: 47 residues, 44363695-44363832Exon11: 51 residues, 44364656-44364805Exon12: 51 residues, 44364939-44365087Exon13: 52 residues, 44365260-44365411Exon14: 62 residues, 44366485-44366666Exon15: 51 residues, 44368888-44369036Exon16: 38 residues, 44370319-44370428Exon17: 24 residues, 44371208-44371274Exon18: 75 residues, 44372240-44372459Exon19: 52 residues, 44372555-44372706Exon20: 27 residues, 44372860-44372935Exon21: 196 residues, 44374906-44375490Exon22: 2 residues, -Jump to PWP2_HUMAN  
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Loci Cluster (Details)Loci: 3292 44597911-44687392 ~-89K 24018(TRPM2)(+)Loci: 3291 44351635-44375490 ~-24K 24002(PWP2H)(+)Link out to UCSC