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0PSD4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePSMD4
Description26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor 1) (af) (asf).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000502 proteasome complex (sensu Eukaryota) (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The von Willebrand factor is a large multimeric glycoprotein found in bloodplasma. Mutant forms are involved in the aetiology of bleeding disorders . In von Willebrand factor.he type A domain (vWF) is the prototype fora protein superfamily. The vWF domain is found in various plasma proteins:complement factors B.2.R3 and CR4; the integrins (I-domains); collagen types VI.II.II and XIV; and other extracellular proteins . Although the majority of VWA-containing proteins are extracellular.he most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription.NA repair.ibosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteinsthat incorporate vWF domains participate in numerous biological events(e.g. cell adhesion.igration.oming.attern formation.nd signaltransduction).nvolving interaction with a large array of ligands . A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands . Foldrecognition algorithms were used to score sequence compatibility with alibrary of known structures: the vWF domain fold was predicted to be adoubly-wound.pen.wisted beta-sheet flanked by alpha-helices . 3D structures have been determined for the I-domains of integrins CD11b(with bound magnesium) and CD11a (with bound manganese) . The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this siterepresents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands . The residues constituting the MIDAS motif in the CD11band CD11a I-domains are completely conserved.ut the manner in which the metal ion is coordinated differs slightly .
  IPR002035:von Willebrand factor, type A
The Ubiquitin Interacting Motif (UIM) was first described in the 26S proteasome subunit PSD4/RPN-10 . It is known to bind multiple ubiquitin and was also found in many proteins involved in the endocytic pathway.ncludingthe PSD4/RPN-10/S5a multiubiquitin binding subunit of the 26S proteasome; the VPS27 vacuolar sorting protein; and ataxin-3. protein involved in ataxia disease.
  IPR003903:Ubiquitin interacting motif
IPR002035:VWA 
Evalue:-11.1249387366083 
Location:2-188IPR003903:UIM 
Evalue:-4.92081880569458 
Location:281-298IPR003903:UIM 
Evalue:-2.55284190177917 
Location:210-227
SequencesProtein: PSD4_HUMAN (377 aa)
mRNA: NM_002810
Local Annotation
Synapse Ontology
modulate the ability to generate LTP
sdb:0252 modulation of the ability to generate LTP  (Evidence:keywords)
KO assignmentK03029
  Level 3 annotation:
    26S proteasome regulatory subunit N10
  Level 2 annotation:
    Proteasome
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 30 residues, 149493820-149493908Exon2: 49 residues, 149501260-149501401Exon3: 40 residues, 149503013-149503128Exon4: 31 residues, 149503931-149504018Exon5: 25 residues, 149504265-149504334Exon6: 74 residues, 149504493-149504709Exon7: 38 residues, 149505103-149505212Exon8: 46 residues, 149505407-149505539Exon9: 24 residues, 149505619-149505687Exon10: 103 residues, 149506272-149506576Exon11: 2 residues, -Jump to PSD4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2548 149493820-149506576 ~-13K 2556(PSMD4)(+)Loci: 3831 149531036-149566511 ~-35K 2560(PIK4CB)(-)Loci: 2549 149851285-149938183 ~-87K 2579(SNX27)(+)Loci: 3832 150010960-150029541 ~-19K 2590(TDRKH)(-)Loci: 3830 149370788-149385728 ~-15K 2543(SEMA6C)(-)Link out to UCSC