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0PROD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePRODH
DescriptionProline oxidase, mitochondrial precursor (ec 1.5.3.-) (proline dehydrogenase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004657 proline dehydrogenase activity (TAS)
0006560 proline metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The proline oxidase/dehydrogenase is responsible for the first step in the conversion of proline to glutamate for use as a carbon and nitrogen source. The enzyme requires FAD as a cofactor.nd is induced by proline.It is found in combination with in bacteria.
  IPR002872:Proline dehydrogenase
IPR002872:Pro_dh 
Evalue:-170.721252441406 
Location:143-498
SequencesProtein: PROD_HUMAN (516 aa)
mRNA: NM_016335
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00309
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 194 residues, 17280294-17280875Exon2: 31 residues, 17280950-17281039Exon3: 35 residues, 17284402-17284501Exon4: 60 residues, 17285828-17286004Exon5: 51 residues, 17286963-17287110Exon6: 33 residues, 17287218-17287311Exon7: 29 residues, 17288854-17288936Exon8: 28 residues, 17289837-17289917Exon9: 41 residues, 17290329-17290446Exon10: 23 residues, 17290627-17290692Exon11: 52 residues, 17292563-17292713Exon12: 13 residues, 17293200-17293235Exon13: 71 residues, 17298502-17298711Exon14: 106 residues, 17303527-17303840Exon15: 56 residues, 17303902-17304066Exon16: 2 residues, -Jump to PROD_HUMAN  
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Loci Cluster (Details)Loci: 4555 16596905-16637258 ~-40K 24143(BID)(-)Loci: 3295 16973558-16994498 ~-21K 24153(TUBA8)(+)Loci: 4556 17280294-17304066 ~-24K 24158(PRODH)(-)Loci: 4557 17543094-17546285 ~-3K 24164(SLC25A1)(-)Loci: 4558 17698223-17799219 ~-101K 24167(HIRA)(-)Loci: 3296 18081986-18090842 ~-9K 24176(SEPT5)(+)Loci: 4559 18243045-18309515 ~-66K 24188(TXNRD2)(-)Loci: 3297 18309308-18336528 ~-27K 24191(COMT)(+)Loci: 3294 16423182-16453647 ~-30K 24138(SLC25A18)(+)Link out to UCSC