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0PRGC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPARGC1A
DescriptionPeroxisome proliferator activated receptor gamma coactivator 1 alpha (ppar gamma coactivator-1 alpha) (ppargc-1 alpha) (pgc-1 alpha) (ligand effect modulator-6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005665 DNA-directed RNA polymerase II, core complex (TAS)
0005634 nucleus (TAS)
0050681 androgen receptor binding (NAS)
0003677 DNA binding (TAS)
0030374 ligand-dependent nuclear receptor transcrip... (TAS)
0003723 RNA binding (TAS)
0016455 RNA polymerase II transcription mediator ac... (TAS)
0008134 transcription factor binding (TAS)
0030521 androgen receptor signaling pathway (NAS)
0050873 brown fat cell differentiation (TAS)
0001678 cell glucose homeostasis (NAS)
0045333 cellular respiration (TAS)
0007586 digestion (TAS)
0019395 fatty acid oxidation (NAS)
0006094 gluconeogenesis (NAS)
0007005 mitochondrion organization and biogenesis (NAS)
0006397 mRNA processing (TAS)
0046321 positive regulation of fatty acid oxidation (TAS)
0045722 positive regulation of gluconeogenesis (TAS)
0035066 positive regulation of histone acetylation (TAS)
0045893 positive regulation of transcription, DNA-d... (NAS)
0006461 protein complex assembly (TAS)
0050821 protein stabilization (TAS)
0042594 response to starvation (NAS)
0008380 RNA splicing (TAS)
0001659 thermoregulation (TAS)
0006367 transcription initiation from RNA polymeras... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-5.56863641738892 
Location:679-719
SequencesProtein: PRGC1_HUMAN (798 aa)
mRNA: AB061325 NM_013261
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK07202
  Level 3 annotation:
    peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
  Level 2 annotation:
    Insulin signaling pathway
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1302 residues, 23402742-23406646Exon2: 52 residues, 23412450-23412602Exon3: 42 residues, 23412944-23413066Exon4: 42 residues, 23423467-23423588Exon5: 37 residues, 23423741-23423846Exon6: 307 residues, 23424410-23425326Exon7: 26 residues, 23435000-23435074Exon8: 17 residues, 23435183-23435229Exon9: 70 residues, 23439120-23439325Exon10: 43 residues, 23440183-23440306Exon11: 67 residues, 23442277-23442472Exon12: 62 residues, 23495472-23495652Exon13: 60 residues, 23500624-23500798Exon14: 2 residues, -Jump to PRGC1_HUMANExon1: 75 residues, 23406423-23406646Exon2: 52 residues, 23412450-23412602Exon3: 42 residues, 23412944-23413066Exon4: 42 residues, 23423467-23423588Exon5: 37 residues, 23423741-23423846Exon6: 307 residues, 23424410-23425326Exon7: 37 residues, 23435000-23435105Exon8: 17 residues, 23435183-23435229Exon9: 70 residues, 23439120-23439325Exon10: 43 residues, 23440183-23440306Exon11: 67 residues, 23442277-23442472Exon12: 62 residues, 23495472-23495652Exon13: 45 residues, 23500624-23500753Exon14: 2 residues, -Jump to PRGC1_HUMAN  
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