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0PREB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePREB
DescriptionProlactin regulatory element-binding protein (mammalian guanine nucleotide exchange factor msec12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes.ncluding phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported.he domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif.esignated a C2 key . Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.
  IPR000008:C2 calcium-dependent membrane targeting
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase.ype II includes soluble quinohaemoprotein with a C-terminal containing haem C.nd type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain . These quinoproteins contain an 8-bladed beta-propeller motif.hich is present in the N-terminal domain of quinoprotein alcohol dehydrogenase.thanol dehydrogenase.nd the heavy chain (alpha subunit) of methanol dehydrogenase () .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011047:Quinonprotein alcohol dehydrogenase-like
IPR001680:WD40 
Evalue:-4.65757751464844 
Location:160-182IPR001680:WD40 
Evalue:-2.79588007926941 
Location:186-223IPR011046:WD40_like 
Evalue:0 
Location:289-357IPR011046:WD40_like 
Evalue:0 
Location:8-52IPR001680:WD_REPEATS_1 
Evalue:0 
Location:0-0
SequencesProtein: PREB_HUMAN (417 aa)
mRNA: NM_013388
Local Annotation
Synapse Ontology
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 251 residues, 27207130-27207880Exon2: 55 residues, 27208043-27208203Exon3: 26 residues, 27208381-27208454Exon4: 60 residues, 27208601-27208775Exon5: 43 residues, 27208974-27209099Exon6: 29 residues, 27209214-27209295Exon7: 75 residues, 27209488-27209709Exon8: 65 residues, 27209903-27210093Exon9: 131 residues, 27210658-27211046Exon10: 2 residues, -Jump to PREB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3152 27047028-27103590 ~-57K 20131(MAPRE3)(+)Loci: 3153 27155437-27162767 ~-7K 20145(EMILIN1)(+)Loci: 4428 27207130-27211046 ~-4K 20152(PREB)(-)Loci: 4429 27330944-27339464 ~-9K 20162(SLC30A3)(-)Loci: 3154 27446892-27453498 ~-7K 20173(SNX17)(+)Loci: 3155 27848089-27856103 ~-8K 20199(+)Loci: 3151 26924466-27024572 ~-100K 20130(DPYSL5)(+)Link out to UCSC