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0PR285_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePRIC285
DescriptionPeroxisomal proliferator-activated receptor a interacting complex 285 kda protein (ppar-alpha interacting complex protein 285).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003713 transcription coactivator activity (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of bacterial and eukaryotic proteins represent both characterized and related sequences to exoribonuclease II (RNase II)and ribonuclease R; a bacterial 3 --> 5 exoribonuclease homologous to RNase II .The size of these proteins range from 644 residues (rnb) to 1250 (SSD1). While their sequence is highly divergent they share a conserved domain in their C-terminal section . It is possible that this domain plays a role in the exonuclease function.
  IPR001900:Ribonuclease II and R
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR001900:RNB 
Evalue:-28.4814853668213 
Location:1335-1555IPR003593:AAA 
Evalue:-3.16115093231201 
Location:536-722IPR003593:AAA 
Evalue:-1.95860731601715 
Location:2166-2504IPR007087:ZnF_C2H2 
Evalue:-1.52287876605988 
Location:40-64IPR001900:RIBONUCLEASE_II 
Evalue:0 
Location:1660-1684IPR007087:ZINC_FINGER_C2H2_2 
Evalue:0 
Location:0-0
SequencesProtein: PR285_HUMAN (2649 aa)
mRNA: NM_001037335
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 429 residues, 61659883-61661167Exon2: 58 residues, 61661724-61661892Exon3: 54 residues, 61661967-61662124Exon4: 75 residues, 61662275-61662494Exon5: 47 residues, 61662591-61662726Exon6: 66 residues, 61662878-61663071Exon7: 41 residues, 61663146-61663263Exon8: 50 residues, 61663397-61663542Exon9: 56 residues, 61663619-61663781Exon10: 46 residues, 61663868-61664000Exon11: 33 residues, 61664084-61664179Exon12: 1239 residues, 61664316-61668028Exon13: 27 residues, 61668174-61668250Exon14: 263 residues, 61668640-61669424Exon15: 216 residues, 61670154-61670796Exon16: 174 residues, 61670944-61671462Exon17: 38 residues, 61672300-61672408Exon18: 63 residues, 61672481-61672665Exon19: 373 residues, 61673904-61675018Exon20: 19 residues, 61675980-61676033Exon21: 2 residues, -Jump to PR285_HUMAN  
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Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC