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0PPOX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPOX
DescriptionProtoporphyrinogen oxidase (ec 1.3.3.4) (ppo).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0005489 electron transporter activity (TAS)
0004729 protoporphyrinogen oxidase activity (TAS)
0006783 heme biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
This entry consists of various amine oxidases.ncluding maize polyamine oxidase (PAO) .-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of theseenzymes.In vertebrates MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters.eurotoxins and trace amines . In lower eukaryotessuch as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium .PAOs in plants.acteria and protozoa oxidise spermidine and spermine to an aminobutyral.iaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines .Other members of this family include tryptophan 2-monooxygenase.utrescine oxidase.orticosteroid binding proteins and antibacterial glycoproteins.
  IPR002937:Amine oxidase
InterPro domains unassigned to SynO:
Protoporphyrinogen oxidase () oxidizes protoporphyrinogen IX to protoporphyrin IX. precursor of heme and chlorophyll.n the penultimate step in heme and porphyrin biosynthesis. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system.lthough the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the aminoend.
  IPR004572:Protoporphyrinogen oxidase
IPR002937:Amino_oxidase 
Evalue:-57.4436988830566 
Location:12-471
SequencesProtein: PPOX_HUMAN (477 aa)
mRNA: NM_000309
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK00231
  Level 3 annotation:
    protoporphyrinogen oxidase
  Level 2 annotation:
    Porphyrin and chlorophyll metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 70 residues, 159402817-159403025Exon2: 33 residues, 159403253-159403348Exon3: 47 residues, 159403513-159403648Exon4: 40 residues, 159403784-159403900Exon5: 46 residues, 159404408-159404541Exon6: 50 residues, 159404845-159404990Exon7: 65 residues, 159405406-159405597Exon8: 22 residues, 159406073-159406134Exon9: 41 residues, 159406319-159406438Exon10: 39 residues, 159406822-159406933Exon11: 52 residues, 159407033-159407183Exon12: 16 residues, 159407320-159407363Exon13: 64 residues, 159407447-159407634Exon14: 2 residues, -Jump to PPOX_HUMAN  
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Loci Cluster (Details)Loci: 2566 159402817-159407634 ~-5K 3130(PPOX)(+)Loci: 3843 159407724-159413938 ~-6K 3131(B4GALT3)(-)Loci: 2567 159435728-159450806 ~-15K 3135(NDUFS2)(+)Loci: 3844 159458706-159460042 ~-1K 3139(APOA2)(-)Loci: 3845 159541150-159546368 ~-5K 3155(MPZ)(-)Loci: 2568 159550789-159601157 ~-50K 3157(SDHC)(+)Loci: 2565 159354514-159357481 ~-3K 3121(NIT1)(+)Link out to UCSC