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0PPCKM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePCK2
DescriptionPhosphoenolpyruvate carboxykinase, mitochondrial precursor (ec 4.1.1.32) (phosphoenolpyruvate carboxylase) (pepck-m).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004611 phosphoenolpyruvate carboxykinase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phosphoenolpyruvate carboxykinase (GTP) (PEPCK) catalyzesthe formation of phosphoenolpyruvate by decarboxylation of oxaloacetate whilehydrolyzing GTP:GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2This is a rate limiting step in gluconeogenesis (the biosynthesis ofglucose). In vertebrates there are two isozymes: a cytosolic form whoseactivity is affected by hormones regulating this metabolic process (such asglucagon.r insulin) and a mitochondrial form.An essential cysteine residue has been proposed to be implicated in thecatalytic mechanism; this residue is located in the central part of PEPCK.
  IPR008209:Phosphoenolpyruvate carboxykinase (GTP)
This N-terminal domain identifies phosphoenolpyruvate carboxykinase (GTP) () and phosphoenolpyruvate carboxykinase (ATP) () (PEPCK) which catalyse the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolyzing either ATP or GTP.
  IPR008210:Phosphoenolpyruvate carboxykinase, N-terminal
IPR008209:PEPCK 
Evalue:-1e+125 
Location:46-640
SequencesProtein: PPCKM_HUMAN (640 aa)
mRNA: NM_004563
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01596
  Level 3 annotation:
    phosphoenolpyruvate carboxykinase (GTP)
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Pyruvate metabolism
    Insulin signaling pathway
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 23633322-23633483Exon2: 84 residues, 23635940-23636186Exon3: 63 residues, 23637251-23637436Exon4: 70 residues, 23637523-23637727Exon5: 64 residues, 23638097-23638285Exon6: 56 residues, 23638606-23638769Exon7: 75 residues, 23639043-23639262Exon8: 48 residues, 23641801-23641939Exon9: 34 residues, 23642208-23642304Exon10: 208 residues, 23642558-23643177Exon11: 2 residues, -Jump to PPCKM_HUMAN  
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Loci Cluster (Details)Loci: 2827 23633322-23643177 ~-10K 10904(PCK2)(+)Loci: 4123 23748628-23755020 ~-6K 10927(CHMP4A)(-)Loci: 4124 23804585-23810583 ~-6K 10943(RABGGTA)(-)Loci: 2826 23610595-23617135 ~-7K 10902(CPNE6)(+)Link out to UCSC