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0PPCKC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionPhosphoenolpyruvate carboxykinase, cytosolic (ec (phosphoenolpyruvate carboxylase) (pepck-c).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004613 phosphoenolpyruvate carboxykinase (GTP) act... (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phosphoenolpyruvate carboxykinase (GTP) (PEPCK) catalyzesthe formation of phosphoenolpyruvate by decarboxylation of oxaloacetate whilehydrolyzing GTP:GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2This is a rate limiting step in gluconeogenesis (the biosynthesis ofglucose). In vertebrates there are two isozymes: a cytosolic form whoseactivity is affected by hormones regulating this metabolic process (such asglucagon.r insulin) and a mitochondrial form.An essential cysteine residue has been proposed to be implicated in thecatalytic mechanism; this residue is located in the central part of PEPCK.
  IPR008209:Phosphoenolpyruvate carboxykinase (GTP)
This N-terminal domain identifies phosphoenolpyruvate carboxykinase (GTP) () and phosphoenolpyruvate carboxykinase (ATP) () (PEPCK) which catalyse the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolyzing either ATP or GTP.
  IPR008210:Phosphoenolpyruvate carboxykinase, N-terminal
SequencesProtein: PPCKC_HUMAN (622 aa)
mRNA: NM_002591
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01596
  Level 3 annotation:
    phosphoenolpyruvate carboxykinase (GTP)
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Pyruvate metabolism
    Insulin signaling pathway
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 42 residues, 55569542-55569665Exon2: 90 residues, 55569833-55570097Exon3: 62 residues, 55570532-55570714Exon4: 70 residues, 55571157-55571361Exon5: 65 residues, 55571489-55571679Exon6: 55 residues, 55572028-55572189Exon7: 77 residues, 55572630-55572855Exon8: 46 residues, 55572943-55573075Exon9: 34 residues, 55573501-55573597Exon10: 372 residues, 55573811-55574922Exon11: 2 residues, -Jump to PPCKC_HUMAN  
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