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0PPA6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACP6
DescriptionLysophosphatidic acid phosphatase type 6 precursor (ec 3.1.3.2) (acid phosphatase 6, lysophosphatidic) (acid phosphatase-like protein 1) (pacpl1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Acid phosphatases () are a heterogeneous group of proteins that hydrolyze phosphate esters.ptimally atlow pH. It has been shown that a number of acid phosphatases.rom both prokaryotes and eukaryotes.hare two regions of sequence similarity.ach centered around a conserved histidine residue. These two histidinesseem to be involved in the enzymes catalytic mechanism . The first histidine is locatedin the N-terminal section and forms a phosphohistidine intermediate while the second is located in the C-terminalsection and possibly acts as proton donor. Enzymes belonging to this family are called histidine acid phosphatasesand include the Escherichia coli pH 2.5 acid phosphatase (gene appA) and glucose-1-phosphatase () (gene agp); yeastconstitutive and repressible acid phosphatases (genes PHO3 and PHO5); Schizosaccharomyces pombe acid phosphatase (gene pho1);Aspergillus awamorii phytases A and B () (gene phyA and phyB); mammalian lysosomal and prostatic acid phosphatase;and several Caenorhabditis elegans hypothetical proteins.
  IPR000560:Histidine acid phosphatase
IPR000560:Acid_phosphat_A 
Evalue:-83.2076110839844 
Location:49-379IPR000560:HIS_ACID_PHOSPHAT_2 
Evalue:0 
Location:0-0
SequencesProtein: PPA6_HUMAN (428 aa)
mRNA: AB031478 NM_016361
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01078
  Level 3 annotation:
    acid phosphatase
  Level 2 annotation:
    Riboflavin metabolism
    gamma-Hexachlorocyclohexane degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 68 residues, 145585791-145585992Exon2: 57 residues, 145586671-145586837Exon3: 34 residues, 145588569-145588665Exon4: 35 residues, 145590875-145590976Exon5: 46 residues, 145592932-145593065Exon6: 31 residues, 145593899-145593987Exon7: 28 residues, 145597698-145597778Exon8: 45 residues, 145598134-145598265Exon9: 45 residues, 145598385-145598514Exon10: 223 residues, 145608575-145609238Exon11: 2 residues, -Jump to PPA6_HUMANExon1: 66 residues, 145585797-145585992Exon2: 57 residues, 145586671-145586837Exon3: 34 residues, 145588569-145588665Exon4: 35 residues, 145590875-145590976Exon5: 46 residues, 145592932-145593065Exon6: 31 residues, 145593899-145593987Exon7: 28 residues, 145597698-145597778Exon8: 45 residues, 145598134-145598265Exon9: 45 residues, 145598385-145598514Exon10: 200 residues, 145608575-145609170Exon11: 2 residues, -Jump to PPA6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3829 145695516-145712066 ~-17K 2401(GJA5)(-)Loci: 2546 145841559-145848017 ~-6K 2402(GJA8)(+)Loci: 3828 145585791-145609238 ~-23K 2398(ACP6)(-)Link out to UCSC