SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0PP1G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPP1CC
DescriptionSerine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g) (protein phosphatase 1c catalytic subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein phosphorylation plays a central role in the regulation of cell functions .ausing the activation or inhibition of many enzymes involved in various biochemical pathways . Kinases and phosphatases are the enzymes responsible for this.nd may themselves be subject to control through the action of hormones and growth factors . Serine/threonine (S/T) phosphatases catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1.P2A.P2B and PP2C. Except for PP2C.hese enzymes are evolutionary related. The catalytic regions of the proteins are well conserved and have a slow mutation rate.uggesting that major changes in these regions are highly detrimental . The metallo-phosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include serine/threonine phosphatases.NA polymerase.xonucleases.nd other phosphatases.
  IPR004843:Metallophosphoesterase
Protein phosphorylation plays a central role in the regulation of cell functions .ausing the activation or inhibition of many enzymes involved in various biochemical pathways . Kinases and phosphatases are the enzymes responsible for this.nd may themselves be subject to control through the action of hormones and growth factors . Serine/threonine(S/T) phosphatases () catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1.P2A.P2B and PP2C. Except for PP2C.hese enzymes are evolutionary related. The catalytic regions of the proteins arewell conserved and have a slow mutation rate.uggesting that major changes in these regions are highly detrimental . Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) have a broad specificity and there are two closely related isoforms of each.lpha and beta. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit and a third variable subunit. Protein phosphatase-2B (PP2B or calcineurin). calcium-dependent enzyme whose activity is stimulated by calmodulin.s composed of two subunits the catalytic A-subunit and the calcium-binding B-subunit. The specificity of PP2B is restricted. Other serine/threonine specific protein phosphatases that have been characterized include mammalian phosphatase-X (PP-X).nd Drosophila phosphatase-V (PP-V).hich are closely related but yet distinct from PP2A; yeast phosphatase PPH3.hich is similar to PP2A.ut with different enzymatic properties; and Drosophila phosphatase-Y (PP-Y).nd yeastphosphatases Z1 and Z2 which are closely related but yet distinct from PP1.
  IPR006186:Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
IPR006186:PP2Ac 
Evalue:-163.193820026016 
Location:30-300
SequencesProtein: PP1G_HUMAN (323 aa)
mRNA: NM_002710
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords)
KO assignmentK06269
  Level 3 annotation:
    protein phosphatase 1, catalytic subunit
  Level 2 annotation:
    Insulin signaling pathway
    Regulation of actin cytoskeleton
    Focal adhesion
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 410 residues, 109642126-109643353Exon2: 47 residues, 109644322-109644457Exon3: 76 residues, 109644659-109644883Exon4: 37 residues, 109646847-109646952Exon5: 79 residues, 109652716-109652947Exon6: 46 residues, 109653957-109654089Exon7: 72 residues, 109664840-109665050Exon8: 2 residues, -Jump to PP1G_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4073 109642126-109665050 ~-23K 9702(PPP1CC)(-)Loci: 2787 109203814-109269506 ~-66K 9677(ATP2A2)(+)Link out to UCSC