SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0PP1B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPP1CB
DescriptionSerine/threonine protein phosphatase pp1-beta catalytic subunit (ec 3.1.3.16) (pp-1b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein phosphorylation plays a central role in the regulation of cell functions .ausing the activation or inhibition of many enzymes involved in various biochemical pathways . Kinases and phosphatases are the enzymes responsible for this.nd may themselves be subject to control through the action of hormones and growth factors . Serine/threonine (S/T) phosphatases catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1.P2A.P2B and PP2C. Except for PP2C.hese enzymes are evolutionary related. The catalytic regions of the proteins are well conserved and have a slow mutation rate.uggesting that major changes in these regions are highly detrimental . The metallo-phosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include serine/threonine phosphatases.NA polymerase.xonucleases.nd other phosphatases.
  IPR004843:Metallophosphoesterase
Protein phosphorylation plays a central role in the regulation of cell functions .ausing the activation or inhibition of many enzymes involved in various biochemical pathways . Kinases and phosphatases are the enzymes responsible for this.nd may themselves be subject to control through the action of hormones and growth factors . Serine/threonine(S/T) phosphatases () catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1.P2A.P2B and PP2C. Except for PP2C.hese enzymes are evolutionary related. The catalytic regions of the proteins arewell conserved and have a slow mutation rate.uggesting that major changes in these regions are highly detrimental . Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) have a broad specificity and there are two closely related isoforms of each.lpha and beta. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit and a third variable subunit. Protein phosphatase-2B (PP2B or calcineurin). calcium-dependent enzyme whose activity is stimulated by calmodulin.s composed of two subunits the catalytic A-subunit and the calcium-binding B-subunit. The specificity of PP2B is restricted. Other serine/threonine specific protein phosphatases that have been characterized include mammalian phosphatase-X (PP-X).nd Drosophila phosphatase-V (PP-V).hich are closely related but yet distinct from PP2A; yeast phosphatase PPH3.hich is similar to PP2A.ut with different enzymatic properties; and Drosophila phosphatase-Y (PP-Y).nd yeastphosphatases Z1 and Z2 which are closely related but yet distinct from PP1.
  IPR006186:Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
IPR006186:PP2Ac 
Evalue:-163.958607314842 
Location:28-298
SequencesProtein: PP1B_HUMAN (326 aa)
mRNA: NM_002709
Local Annotation
Synapse Ontology
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK06269
  Level 3 annotation:
    protein phosphatase 1, catalytic subunit
  Level 2 annotation:
    Insulin signaling pathway
    Regulation of actin cytoskeleton
    Focal adhesion
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 140 residues, 28828129-28828546Exon2: 46 residues, 28853220-28853352Exon3: 79 residues, 28855178-28855409Exon4: 37 residues, 28858107-28858212Exon5: 26 residues, 28860276-28860348Exon6: 52 residues, 28865027-28865179Exon7: 47 residues, 28870232-28870367Exon8: 1249 residues, 28875568-28879309Exon9: 2 residues, -Jump to PP1B_HUMAN  
Tune and view alternative isoforms