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0POMT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionProtein o-mannosyl-transferase 2 (ec (dolichyl-phosphate- mannose--protein mannosyltransferase 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
This is a domain found in ryanodine.nositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1..-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules . The function is modulated by Ca2+.g2+.TP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) . protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.
InterPro domains unassigned to SynO:
The biosynthesis of disaccharides.ligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These are enzymes that catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules.orming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar.ucleotide monophospho-sugar and sugar phosphates () and related proteins into distinct sequence based families has been described . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences.everal of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form clans.Dolichyl-phosphate-mannose-protein mannosyltransferase proteins belong to the glycosyltransferase family 39 () and are responsible for O-linked glycosylation of proteins. They catalyse the reaction: Dolichyl phosphate D-mannose + protein -> dolichyl phosphate + O-D-mannosyl-protein.The transfer of mannose to seryl and threonyl residues of secretory proteins is catalyzed by a family of protein mannosyltransferases in Saccharomyces cerevisiae coded for by seven genes (PMT1-7). Protein O-glycosylation is essential for cell wall rigidity and cell integrity and this protein modification is vital for S. cerevisiae .
  IPR003342:Glycosyl transferase, family 39
SequencesProtein: POMT2_HUMAN (750 aa)
mRNA: NM_013382
Local Annotation
Synapse Ontology
Any process that activates or increases the rate, frequency or extent of synaptic growth at neuromuscular junction.
sdb:0047 positive regulation of synaptic growth at neuromuscular junction  (Evidence:domains)
those channels, like InsP3-gated calcium channels which activated by InsP3 and release calcium into plasma.
sdb:0117 ionotropic receptor on the ER  (Evidence:domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:domains)
activation of calmodulin-dependent protein kinases
sdb:0204 activation of calmodulin-dependent protein kinase  (Evidence:domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:domains)
calcium dependent short-term forms of presynaptic plasticity
sdb:0234 calcium dependent short-term forms of presynaptic plasticity  (Evidence:domains)
intracellular calcium store release to change the concentration of cytosolic calcium.
sdb:0321 intracellular calcium store release  (Evidence:domains)
KO assignmentK00728
  Level 3 annotation:
    dolichyl-phosphate-mannose-protein mannosyltransferase
  Level 2 annotation:
    Protein folding and associated processing
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 842 residues, 76811053-76813577Exon2: 40 residues, 76814489-76814604Exon3: 49 residues, 76814824-76814965Exon4: 37 residues, 76815918-76816024Exon5: 22 residues, 76816116-76816176Exon6: 26 residues, 76816487-76816559Exon7: 27 residues, 76819892-76819969Exon8: 32 residues, 76821045-76821137Exon9: 52 residues, 76821576-76821728Exon10: 28 residues, 76822839-76822918Exon11: 25 residues, 76824857-76824927Exon12: 24 residues, 76827409-76827476Exon13: 38 residues, 76832259-76832369Exon14: 29 residues, 76834784-76834867Exon15: 37 residues, 76835550-76835657Exon16: 55 residues, 76837185-76837345Exon17: 38 residues, 76838930-76839039Exon18: 38 residues, 76840787-76840896Exon19: 37 residues, 76842432-76842537Exon20: 30 residues, 76848044-76848129Exon21: 149 residues, 76856529-76856970Exon22: 2 residues, -Jump to POMT2_HUMAN  
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