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0POLS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePOLS
DescriptionDna polymerase sigma (ec 2.7.7.7) (topoisomerase-related function protein 4-1) (trf4-1) (lak-1) (dna polymerase kappa).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0003677 DNA binding (TAS)
0006281 DNA repair (NAS)
0007062 sister chromatid cohesion (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
These PAP/25A associated domains are found in uncharacterised eukaryotic proteins. number of which are described as topoisomerase 1-related though they appear to have little or no homology to topoisomerase 1. The signatures that define this group of sequences often occur towards the C-terminus after the PAP/25A core domain .
  IPR002058:PAP/25A-associated
A small region that overlaps with a nuclear localization signal and binds to the RNA primer contains three aspartates that are essential for catalysis. Sequence and secondary structure comparisons of regions surrounding these aspartates with sequences of other polymerases revealed a significant homology to the palm structure of DNA polymerase beta.erminal deoxynucleotidyltransferase and DNA polymerase IV of Saccharomyces cerevisiae.ll members of the family X of polymerases. This homology extends as far as cca: tRNA nucleotidyltransferase and streptomycin adenylyltransferase.n antibiotic resistance factor .Proteins containing this domain include kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase inactivates antibiotics by catalysing the addition of a nucleotidyl group onto the drug. In experiments.n2+ strongly stimulated this reaction due to a 50-fold lower Ki for 8-azido-ATP in the presence of Mn2+. Mutations of the highly conservedAsp residues 113.15.nd 167.ritical for metal binding in the catalytic domain of bovine poly(A) polymerase.ed to a strongreduction of cross-linking efficiency.nd Mn2+ no longer stimulated the reaction. Mutations in the region of the "helical turn motif"(a domain binding the triphosphate moiety of the nucleotide) and in the suspected nucleotide-binding helix of bovine poly(A) polymeraseimpaired ATP binding and catalysis. The results indicate that ATP is bound in part by the helical turn motif and in part by a region thatmay be a structural analogue of the fingers domain found in many polymerases.
  IPR002934:DNA polymerase, beta-like region
IPR002058:PAP_assoc 
Evalue:-25 
Location:178-238IPR002934:NTP_transf_2 
Evalue:-17.4685211181641 
Location:15-124
SequencesProtein: POLS_HUMAN (542 aa)
mRNA: NM_006999
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03514
  Level 3 annotation:
    DNA polymerase sigma subunit
  Level 2 annotation:
    DNA polymerase
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 32 residues, 6767717-6767812Exon2: 43 residues, 6790622-6790746Exon3: 17 residues, 6791795-6791842Exon4: 42 residues, 6792844-6792965Exon5: 38 residues, 6795602-6795710Exon6: 45 residues, 6796824-6796953Exon7: 73 residues, 6799326-6799540Exon8: 44 residues, 6801576-6801703Exon9: 35 residues, 6802669-6802770Exon10: 59 residues, 6803443-6803616Exon11: 55 residues, 6804151-6804310Exon12: 57 residues, 6805985-6806150Exon13: 768 residues, 6807863-6810161Exon14: 2 residues, -Jump to POLS_HUMAN  
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Loci Cluster (Details)Loci: 3444 6767717-6810161 ~-42K 28582(POLS)(+)Loci: 3443 6686562-6722673 ~-36K 28581(SRD5A1)(+)Link out to UCSC