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0POLI_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePOLI
DescriptionDna polymerase iota (ec 2.7.7.7) (rad30 homolog b) (eta2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005654 nucleoplasm (TAS)
0016000 iota DNA polymerase activity (TAS)
0006281 DNA repair (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
In Escherichia coli.V and many chemicals appear to cause mutagenesis by aprocess of translesion synthesis that requires DNA polymerase III and theSOS-regulated proteins UmuD.muC and RecA. This machinery allows thereplication to continue through DNA lesion.nd therefore avoid lethalinterruption of DNA replication after DNA damage .The UmuC is a well conserved protein in prokaryotes.ith a homologue in yeast.Proteins currently known to belong to this family are listed below: Escherichia coli MucB protein. Plasmid-born analog of the UmuC protein. Yeast Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents. Salmonella typhimurium ImpB protein. Plasmid-born analog of the UmuC protein. Bacterial UmuC protein. Escherichia coli DNA-damage-inducible protein P (DinP). Salmonella typhimurium SamB homologue of UmuC plasmid associated.
  IPR001126:UMUC-like DNA-repair protein
This group represents a DNA polymerase iota.AD30B type. Please see the following relevant reference: .
  IPR012246:DNA polymerase iota, RAD30B
IPR001126:IMS 
Evalue:-62.5086364746094 
Location:33-415
SequencesProtein: POLI_HUMAN (715 aa)
mRNA: NM_007195
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03510
  Level 3 annotation:
    DNA polymerase iota subunit
  Level 2 annotation:
    DNA polymerase
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 36 residues, 50049922-50050029Exon2: 44 residues, 50051727-50051853Exon3: 57 residues, 50054293-50054458Exon4: 53 residues, 50058070-50058223Exon5: 81 residues, 50061034-50061271Exon6: 61 residues, 50063204-50063383Exon7: 32 residues, 50064289-50064381Exon8: 45 residues, 50067648-50067779Exon9: 70 residues, 50072200-50072406Exon10: 360 residues, 50074016-50075090Exon11: 2 residues, -Jump to POLI_HUMAN  
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