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0PMYT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePKMYT1
DescriptionMembrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (ec 2.7.1.37) (myt1 kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005794 Golgi apparatus (TAS)
0005624 membrane fraction (TAS)
0005515 protein binding (IPI)
0004672 protein kinase activity (TAS)
0000079 regulation of cyclin dependent protein kina... (TAS)
0007088 regulation of mitosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-51.0362129211426 
Location:110-359
SequencesProtein: PMYT1_HUMAN (499 aa)
mRNA: NM_004203 NM_182687
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK06633
  Level 3 annotation:
    membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 91 residues, 2962794-2963066Exon2: 28 residues, 2963139-2963217Exon3: 54 residues, 2964001-2964159Exon4: 59 residues, 2964246-2964419Exon5: 37 residues, 2964551-2964658Exon6: 166 residues, 2965320-2965814Exon7: 124 residues, 2966665-2967033Exon8: 90 residues, 2969649-2969914Exon9: 64 residues, 2970287-2970475Exon10: 2 residues, -Jump to PMYT1_HUMANExon1: 91 residues, 2962794-2963066Exon2: 40 residues, 2963139-2963255Exon3: 54 residues, 2964001-2964159Exon4: 59 residues, 2964246-2964419Exon5: 37 residues, 2964551-2964658Exon6: 166 residues, 2965320-2965814Exon7: 124 residues, 2966665-2967033Exon8: 90 residues, 2969649-2969914Exon9: 64 residues, 2970287-2970475Exon10: 2 residues, -Jump to PMYT1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2919 3036682-3050723 ~-14K 13385(MMP25)(+)Loci: 4203 3232028-3246628 ~-15K 13403(MEFV)(-)Loci: 2920 3273487-3281456 ~-8K 13405(ZNF263)(+)Loci: 4204 3571183-3601586 ~-30K 13423(BTBD12)(-)Loci: 4205 3648039-3707514 ~-59K 13426(TRAP1)(-)Loci: 4206 3717719-3870723 ~-153K 13429(CREBBP)(-)Loci: 4202 2962794-2970475 ~-8K 13372(PKMYT1)(-)Link out to UCSC