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0PMM2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePMM2
DescriptionPhosphomannomutase 2 (ec 5.4.2.8) (pmm 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004615 phosphomannomutase activity (TAS)
0009298 GDP-mannose biosynthesis (TAS)
0006486 protein amino acid glycosylation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This enzyme () is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  IPR005002:Eukaryotic phosphomannomutase
This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class II subfamilies are characterized by a domain that is located between the second and third conserved catalytic motifs of the superfamily domain. The IIB subfamily is distinguished from the IIA subfamily () by homology and the predicted secondary structure of this domain by PSI-PRED. The IIB subfamilys Class II domain has the following predicted structure: Helix-Sheet-Sheet-(Helix or Sheet)-Helix-Sheet-(variable)-Helix-Sheet-Sheet. The IIB subfamily consists of trehalose-6-phosphatase.lant and cyanobacterial sucrose-phosphatase and a closely related group of bacterial and archaeal sequences.ukaryotic phosphomannomutase. large subfamily of Cof-like hydrolases.ontaining many closely related bacterial sequences. hypothetical equivalog containing the Escherichia coli YedP protein.s well as two other small clusters whose relationship to the other groups is unclear.
  IPR006379:HAD-superfamily hydrolase, subfamily IIB
IPR005002:PMM 
Evalue:-175.309799194336 
Location:28-246
SequencesProtein: PMM2_HUMAN (246 aa)
mRNA: BC008310
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK01840
  Level 3 annotation:
    phosphomannomutase
  Level 2 annotation:
    Fructose and mannose metabolism
K07024
  Level 3 annotation:
    
  Level 2 annotation:
    General function prediction only
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 8799228-8799306Exon2: 39 residues, 8803156-8803268Exon3: 27 residues, 8806124-8806201Exon4: 32 residues, 8807673-8807765Exon5: 35 residues, 8812436-8812536Exon6: 27 residues, 8812995-8813071Exon7: 40 residues, 8814348-8814464Exon8: 538 residues, 8849081-8850689Exon9: 2 residues, -Jump to PMM2_HUMAN  
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Loci Cluster (Details)Loci: 2924 8799228-8850689 ~-51K 13485(PMM2)(+)Loci: 2923 8675945-8785932 ~-110K 13482(ABAT)(+)Link out to UCSC