SynDB Home Page
SynDB Home Page

blue bulletSynDB protein details  

Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0PMGT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionProtein o-linked-mannose beta-1,2-n-acetylglucosaminyltransferase 1 (ec 2.4.1.-) (pomgnt1) (udp-glcnac:alpha-d-mannoside beta-1,2-n- acetylglucosaminyltransferase i.2) (gnt i.2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The biosynthesis of disaccharides.ligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These are enzymes that catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules.orming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar.ucleotide monophospho-sugar and sugar phosphates () and related proteins into distinct sequence based families has been described . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences.everal of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form clans.Alpha-1.-mannosyl-glycoprotein beta-1.-N-acetylglucosaminyltransferase (GNT-I.LCNAC-T I) transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus.nd is probably distributed in all tissues. The catalytic domain is located at the C-terminus . These proteins are members of the glycosyl transferase family 13 ()
  IPR004139:Glycosyl transferase, family 13
SequencesProtein: PMGT1_HUMAN (660 aa)
mRNA: NM_017739
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK00754
  Level 3 annotation:
  Level 2 annotation:
    Fructose and mannose metabolism
    Glycerolipid metabolism
    N-Glycan biosynthesis
    High-mannose type N-glycan biosynthesis
    O-Glycan biosynthesis
    Glycosphingolipid metabolism
    Blood group glycolipid biosynthesis - neo-lactoseries
    Globoside metabolism
    Ganglioside biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 226 residues, 46426941-46427616Exon2: 38 residues, 46427716-46427826Exon3: 47 residues, 46428112-46428248Exon4: 17 residues, 46428731-46428776Exon5: 23 residues, 46428978-46429043Exon6: 44 residues, 46430356-46430482Exon7: 45 residues, 46430566-46430695Exon8: 26 residues, 46430776-46430849Exon9: 21 residues, 46431158-46431217Exon10: 16 residues, 46431432-46431474Exon11: 30 residues, 46431563-46431647Exon12: 27 residues, 46431822-46431898Exon13: 25 residues, 46432113-46432184Exon14: 44 residues, 46432532-46432660Exon15: 35 residues, 46432811-46432910Exon16: 41 residues, 46433102-46433220Exon17: 40 residues, 46434069-46434183Exon18: 24 residues, 46434270-46434336Exon19: 41 residues, 46434989-46435108Exon20: 40 residues, 46435228-46435343Exon21: 58 residues, 46435960-46436130Exon22: 32 residues, 46436594-46436685Exon23: 2 residues, -Jump to PMGT1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3799 46426941-46436685 ~-10K 1371(POMGNT1)(-)Loci: 2515 46632578-46652099 ~-20K 1383(FAAH)(+)Loci: 3800 46873299-46906615 ~-33K 1396(-)Loci: 2514 46041871-46274383 ~-233K 1363(MAST2)(+)Link out to UCSC