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0PLXD1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionPlexin d1 precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found at C terminus of various plexins (e.g. ). Plexins are receptors for semaphorins.nd plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels . The cytoplasmic region.hich has been called a SEX domain .nd is involved in downstream signalling pathways.y interaction with proteins such as Rac1.hoD.nd1 and other plexins .
  IPR013548:Plexin cytoplasmic region
This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding.The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation.otility.nd invasion of extracellular matrices (scattering) .
  IPR002909:Cell surface receptor IPT/TIG
This is a cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found in plexin () . Two copies of the repeat are found in mahogany protein. A related Caenorhabditis elegans protein () contains four copies of the repeat.hile the Met receptor contains a single copy of the repeat.
This is a domain that has been found in plexins.emaphorins and integrins. Plexin is involved in the development of neural and epithelial tissues; semaphorins induce the collapse and paralysis of neuronal growth cones; and integrins may mediate adhesive or migratory functions of epithelial cells.
The Sema domain occurs in semaphorins.hich are a large family of secreted and transmembrane proteins.ome of which function as repellent signals during axon guidance. Sema domains also occur in a hepatocyte growth factor receptor.n SEX protein and in viral proteins.CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA.D3 and CD2 induced T cell proliferation.ncreases CD45 induced T cell adhesion.nduces B cell homotypic adhesion and down-regulates B cell expression of CD23.The Sema domain is characterised by a conserved set of cysteine residues.hich form four disulfide bonds to stabilise the structure. The Sema domainfold is a variation of the beta propeller topology.ith seven blades radiallyarranged around a central axis. Each blade contains a four-stranded (strands A to D) antiparallel beta sheet. The inner strand of eachblade (A) lines the channel at the center of the propeller.ith strands B andC of the same repeat radiating outward.nd strand D of the next repeatforming the outer edge of the blade. The large size of the Sema domain is notdue to a single inserted domain but results from the presence of additionnalsecondary structure elements inserted in most of the blades. The Sema domainuses a loop and hook system to close the circle between the first and thelast blades. The blades are constructed sequentially with an N-terminal beta-strand closing the circle by providing the outermost strand (D) of the seventh(C-terminal) blade. The beta-propeller is further stabilized by an extensionof the N-terminus.roviding an additional.ifth beta-strand on the outeredge of blade 6 .CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at
  IPR001627:Semaphorin/CD100 antigen
Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to and/or Cdc42.nactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008936:Rho GTPase activation protein
SequencesProtein: PLXD1_HUMAN (1925 aa)
mRNA: NM_015103
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK06822
  Level 3 annotation:
    plexin D
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 419 residues, 130756707-130757961Exon2: 27 residues, 130758149-130758224Exon3: 49 residues, 130758615-130758756Exon4: 51 residues, 130759960-130760108Exon5: 56 residues, 130761152-130761316Exon6: 37 residues, 130761862-130761967Exon7: 13 residues, 130762221-130762256Exon8: 23 residues, 130763178-130763242Exon9: 36 residues, 130763332-130763436Exon10: 54 residues, 130764319-130764476Exon11: 51 residues, 130764626-130764773Exon12: 68 residues, 130766872-130767071Exon13: 45 residues, 130767419-130767550Exon14: 37 residues, 130768059-130768164Exon15: 39 residues, 130769024-130769137Exon16: 38 residues, 130769230-130769338Exon17: 40 residues, 130771375-130771490Exon18: 52 residues, 130772318-130772468Exon19: 90 residues, 130772572-130772836Exon20: 32 residues, 130773041-130773132Exon21: 58 residues, 130773209-130773377Exon22: 48 residues, 130774141-130774281Exon23: 35 residues, 130774374-130774474Exon24: 52 residues, 130775126-130775278Exon25: 53 residues, 130775868-130776023Exon26: 33 residues, 130777001-130777095Exon27: 32 residues, 130777298-130777388Exon28: 37 residues, 130779861-130779966Exon29: 36 residues, 130785099-130785202Exon30: 38 residues, 130785657-130785766Exon31: 61 residues, 130785917-130786095Exon32: 45 residues, 130787484-130787614Exon33: 35 residues, 130787704-130787805Exon34: 46 residues, 130788120-130788252Exon35: 61 residues, 130790883-130791060Exon36: 498 residues, 130806861-130808351Exon37: 2 residues, -Jump to PLXD1_HUMAN  
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Loci Cluster (Details)Loci: 3375 130081143-130114646 ~-34K 26440(ACAD9)(+)Loci: 4632 130289107-130323309 ~-34K 26447(-)Loci: 4633 130602854-130630184 ~-27K 26461(-)Loci: 4634 130632482-130641542 ~-9K 26462(MBD4)(-)Loci: 4635 130756707-130808351 ~-52K 26476(PLXND1)(-)Loci: 4636 130849326-131081999 ~-233K 26481(TMCC1)(-)Loci: 3376 131176252-131179470 ~-3K 26482(TRH)(+)Loci: 3374 129927668-130016331 ~-89K 26437(RAB7)(+)Link out to UCSC