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0PLXB1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePLXNB1
DescriptionPlexin b1 precursor (semaphorin receptor sep).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (NAS)
0017154 semaphorin receptor activity (TAS)
0030215 semaphorin receptor binding (TAS)
0016477 cell migration (NAS)
0007242 intracellular signaling cascade (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found at C terminus of various plexins (e.g. ). Plexins are receptors for semaphorins.nd plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels . The cytoplasmic region.hich has been called a SEX domain .nd is involved in downstream signalling pathways.y interaction with proteins such as Rac1.hoD.nd1 and other plexins .
  IPR013548:Plexin cytoplasmic region
This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding.The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation.otility.nd invasion of extracellular matrices (scattering) .
  IPR002909:Cell surface receptor IPT/TIG
This is a cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found in plexin () . Two copies of the repeat are found in mahogany protein. A related Caenorhabditis elegans protein () contains four copies of the repeat.hile the Met receptor contains a single copy of the repeat.
  IPR002165:Plexin
This is a domain that has been found in plexins.emaphorins and integrins. Plexin is involved in the development of neural and epithelial tissues; semaphorins induce the collapse and paralysis of neuronal growth cones; and integrins may mediate adhesive or migratory functions of epithelial cells.
  IPR003659:Plexin/semaphorin/integrin
The Sema domain occurs in semaphorins.hich are a large family of secreted and transmembrane proteins.ome of which function as repellent signals during axon guidance. Sema domains also occur in a hepatocyte growth factor receptor.n SEX protein and in viral proteins.CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA.D3 and CD2 induced T cell proliferation.ncreases CD45 induced T cell adhesion.nduces B cell homotypic adhesion and down-regulates B cell expression of CD23.The Sema domain is characterised by a conserved set of cysteine residues.hich form four disulfide bonds to stabilise the structure. The Sema domainfold is a variation of the beta propeller topology.ith seven blades radiallyarranged around a central axis. Each blade contains a four-stranded (strands A to D) antiparallel beta sheet. The inner strand of eachblade (A) lines the channel at the center of the propeller.ith strands B andC of the same repeat radiating outward.nd strand D of the next repeatforming the outer edge of the blade. The large size of the Sema domain is notdue to a single inserted domain but results from the presence of additionnalsecondary structure elements inserted in most of the blades. The Sema domainuses a loop and hook system to close the circle between the first and thelast blades. The blades are constructed sequentially with an N-terminal beta-strand closing the circle by providing the outermost strand (D) of the seventh(C-terminal) blade. The beta-propeller is further stabilized by an extensionof the N-terminus.roviding an additional.ifth beta-strand on the outeredge of blade 6 .CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001627:Semaphorin/CD100 antigen
Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho.ac and/or Cdc42.nactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008936:Rho GTPase activation protein
IPR013548:Plexin_cytopl 
Evalue:-1e+125 
Location:1561-2102IPR001627:Sema 
Evalue:-112.602059991328 
Location:35-463IPR002909:TIG 
Evalue:-24.4948501586914 
Location:1252-1375IPR002909:TIG 
Evalue:-22.9208183288574 
Location:1070-1160IPR002909:IPT 
Evalue:-22.4685210829577 
Location:1161-1249IPR002165:PSI 
Evalue:-18.9208183288574 
Location:481-534IPR002165:PSI 
Evalue:-8.69896984100342 
Location:1021-1068IPR003659:PSI 
Evalue:-2.82390874094432 
Location:628-678IPR008936:Rho_GAP 
Evalue:0 
Location:9-31
SequencesProtein: PLXB1_HUMAN (2135 aa)
mRNA: NM_002673
Local Annotation
Synapse Ontology
?
sdb:0297 NMDA receptor  (Evidence:keywords)
KO assignmentK06821
  Level 3 annotation:
    plexin B
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 246 residues, 48420266-48421001Exon2: 27 residues, 48422134-48422209Exon3: 27 residues, 48423233-48423309Exon4: 23 residues, 48423437-48423502Exon5: 51 residues, 48425740-48425888Exon6: 55 residues, 48425982-48426143Exon7: 59 residues, 48426317-48426490Exon8: 30 residues, 48426708-48426793Exon9: 36 residues, 48426867-48426971Exon10: 58 residues, 48427280-48427449Exon11: 51 residues, 48428275-48428422Exon12: 24 residues, 48428650-48428717Exon13: 61 residues, 48428854-48429033Exon14: 74 residues, 48429154-48429372Exon15: 35 residues, 48429481-48429582Exon16: 51 residues, 48430082-48430231Exon17: 61 residues, 48430307-48430484Exon18: 83 residues, 48431211-48431454Exon19: 59 residues, 48431588-48431760Exon20: 61 residues, 48431995-48432172Exon21: 47 residues, 48432443-48432580Exon22: 37 residues, 48432758-48432864Exon23: 52 residues, 48434323-48434475Exon24: 59 residues, 48434603-48434776Exon25: 33 residues, 48434861-48434955Exon26: 43 residues, 48435329-48435452Exon27: 43 residues, 48435656-48435779Exon28: 229 residues, 48435989-48436670Exon29: 38 residues, 48437077-48437186Exon30: 38 residues, 48437260-48437369Exon31: 54 residues, 48437640-48437797Exon32: 46 residues, 48438086-48438219Exon33: 35 residues, 48438517-48438618Exon34: 45 residues, 48438743-48438872Exon35: 63 residues, 48439177-48439360Exon36: 373 residues, 48439917-48441030Exon37: 19 residues, 48441693-48441746Exon38: 2 residues, -Jump to PLXB1_HUMAN  
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Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC