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0PLS1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePLSCR1
DescriptionPhospholipid scramblase 1 (pl scramblase 1) (ca(2+)-dependent phospholipid scramblase 1) (erythrocyte phospholipid scramblase) (mmtra1b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (TAS)
0005509 calcium ion binding (NAS)
0017128 phospholipid scramblase activity (TAS)
0017121 phospholipid scrambling (TAS)
0030168 platelet activation (NAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury .
  IPR005552:Scramblase
IPR005552:Scramblase 
Evalue:-147.070587158203 
Location:86-307
SequencesProtein: PLS1_HUMAN (318 aa)
mRNA: NM_021105
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 308 residues, 147715657-147716578Exon2: 56 residues, 147717482-147717644Exon3: 56 residues, 147722020-147722182Exon4: 75 residues, 147722309-147722530Exon5: 16 residues, 147726081-147726124Exon6: 74 residues, 147729090-147729308Exon7: 29 residues, 147733946-147734027Exon8: 10 residues, 147737016-147737042Exon9: 83 residues, 147744943-147745186Exon10: 2 residues, -Jump to PLS1_HUMAN  
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